Abstract
The past decade and a half has been characterized by numerous emerging infectious diseases. With each new threat, there has been a call for rapid vaccine development. Pathogens such as the Middle East Respiratory Syndrome coronavirus (MERS-CoV) and the Zika virus represent either new viral entities or viruses emergent in new geographic locales and characterized by novel complications. Both serve as paradigms for the global spread that can accompany new pathogens. In this paper, we review the epidemiology and pathogenesis of MERS-CoV and Zika virus with respect to vaccine development. The challenges in vaccine development and the approach to clinical trial design to test vaccine candidates for disease entities with a changing epidemiology are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2918-2930 |
| Number of pages | 13 |
| Journal | Human Vaccines and Immunotherapeutics |
| Volume | 13 |
| Issue number | 12 |
| DOIs | |
| State | Published - Nov 14 2017 |
Keywords
- Coronavirus
- DNA vaccine
- Emerging infectious disease
- Epidemic
- Epidemiology
- Flavivirus
- MERS-CoV
- Vaccine
- Zika virus
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Pharmacology