Varicella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3

Medicine & Life Sciences

• Immediate-Early Proteins 98%
• Human Herpesvirus 3 80%
• Innate Immunity 60%
• Interferons 60%
• Varicella Zoster Virus Infection 39%
• Sendai virus 37%
• benzyloxycarbonylleucyl-leucyl-leucine aldehyde 12%
• Virus Activation 12%
• Proteasome Inhibitors 11%
• Interferon-beta 10%
• Messenger RNA 10%
• Ectopic Gene Expression 10%
• Response Elements 10%
• Indirect Fluorescent Antibody Technique 9%
• Proteasome Endopeptidase Complex 9%
• Ubiquitin 9%
• Reverse Transcription 8%
• Antiviral Agents 8%
• Genes 7%
• Down-Regulation 6%
• Western Blotting 6%
• Cytokines 5%
• Polymerase Chain Reaction 5%
• Therapeutics 1%

Agriculture & Biology

• Human alphaherpesvirus 3 100%
• interferons 74%
• innate immunity 65%
• Murine respirovirus 40%
• degradation 39%
• proteins 22%
• infection 14%
• proteasome inhibitors 14%
• interferon-beta 13%
• promoter regions 13%
• response elements 11%
• proteasome endopeptidase complex 10%
• ubiquitin 10%
• assays 9%
• fluorescent antibody technique 8%
• cells 8%
• cytokines 8%
• pathogenesis 8%
• Western blotting 7%
• reverse transcriptase polymerase chain reaction 7%
• screening 6%
• secretion 6%
• genes 6%