Abstract
Warm autoimmune hemolytic anemia (WAIHA), the most common of the relatively uncommon autoimmune-mediated hemolytic anemias (AIHAs), is mediated by polyclonal immunoglobulin (Ig)G autoantibodies in most cases. Herein, we present a case of WAIHA involving a direct antiglobulin test (DAT) with an initially negative result. Using a modified DAT protocol, repeat testing of the same specimen material from a previously healthy 53-year-old man yielded positive results. This case demonstrates that investigation of an apparently negative DAT result plays a critical role in the differential diagnosis of patients with rapidly progressing hemolytic anemia and the reversal of that decline.
Original language | English (US) |
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Pages (from-to) | 227-232 |
Number of pages | 6 |
Journal | Laboratory Medicine |
Volume | 47 |
Issue number | 3 |
DOIs | |
State | Published - Aug 1 2016 |
Keywords
- DAT negative
- DAT protocol
- WAIHA diagnosis
- WAIHA treatment
- direct antiglobulin test (DAT)
- warm autoimmune hemolytic anemia (WAIHA)
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical