TY - JOUR
T1 - White matter microstructure associated with anhedonia among individuals with bipolar disorders and high-risk for bipolar disorders
AU - Diaz, Alexandre Paim
AU - Fernandes, Brisa S.
AU - Teixeira, Antonio Lucio
AU - Mwangi, Benson
AU - Hasan, Khader M.
AU - Wu, Mon Ju
AU - Selvaraj, Sudhakar
AU - Suen, Paulo
AU - Zanao, Tamires Araujo
AU - Brunoni, Andre R.
AU - Sanches, Marsal
AU - Soares, Jair C.
N1 - Funding Information:
Funding information: NIMH grant number R01MH085667, PI: Jair C. Soares.
Funding Information:
Funding information: NIMH grant number R01MH085667, PI: Jair C. Soares. This study was presented as a poster in the National Network of Depression Centers (NNDC) 12th Annual Conference. APD is supported by a 2020 NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation.
Funding Information:
Funding information: NIMH grant number R01MH085667, PI: Jair C. Soares. This study was presented as a poster in the National Network of Depression Centers (NNDC) 12th Annual Conference. APD is supported by a 2020 NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation.
Publisher Copyright:
© 2021
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Background: Anhedonia - a key symptom of depression - is highly associated with poorer outcomes and suicidal behavior. Alterations in the circuitry of reward-related brain regions have been robustly associated with anhedonia in unipolar depression, but not bipolar disorder (BD). We investigated white matter microstructures associated with anhedonia in participants with BD types I and II and first-degree relatives of patients with BD (BD-siblings). Methods: Eighty participants (BD types I and II: 56 [70%], and BD-siblings: 24 [30%]) underwent diffusion tensor imaging (DTI); Fractional anisotropy (FA) of different tracts were computed. Anhedonia was assessed using item 8, (“inability to feel'') of the MADRS scale. General linear models were used to compare the FA of different tracts in participants with and without anhedonia controlling for several clinical and demographic variables. Results: The mean age of the sample was 37 (± 11) years old, and 68.8% were female. Participants with anhedonia (32.5%) presented lower mean FA in the left uncinate fasciculus (UF) (p = 0.005), right temporal endings of the superior longitudinal fasciculus (SLFT) (p = 0.04), and in the left and right parietal endings of the superior longitudinal fasciculus (SLFP) (p = 0.003, and p = 0.04, respectively). Similar comparisons between participants with or without current depressive episodes and between participants with or without inner tension according to the MADRS did not show significant differences, specificity of the findings for anhedonia. Conclusions: Lower FA in the left UF and SLF are potential neuroimaging markers of anhedonia in individuals with BD and high-risk for BD.
AB - Background: Anhedonia - a key symptom of depression - is highly associated with poorer outcomes and suicidal behavior. Alterations in the circuitry of reward-related brain regions have been robustly associated with anhedonia in unipolar depression, but not bipolar disorder (BD). We investigated white matter microstructures associated with anhedonia in participants with BD types I and II and first-degree relatives of patients with BD (BD-siblings). Methods: Eighty participants (BD types I and II: 56 [70%], and BD-siblings: 24 [30%]) underwent diffusion tensor imaging (DTI); Fractional anisotropy (FA) of different tracts were computed. Anhedonia was assessed using item 8, (“inability to feel'') of the MADRS scale. General linear models were used to compare the FA of different tracts in participants with and without anhedonia controlling for several clinical and demographic variables. Results: The mean age of the sample was 37 (± 11) years old, and 68.8% were female. Participants with anhedonia (32.5%) presented lower mean FA in the left uncinate fasciculus (UF) (p = 0.005), right temporal endings of the superior longitudinal fasciculus (SLFT) (p = 0.04), and in the left and right parietal endings of the superior longitudinal fasciculus (SLFP) (p = 0.003, and p = 0.04, respectively). Similar comparisons between participants with or without current depressive episodes and between participants with or without inner tension according to the MADRS did not show significant differences, specificity of the findings for anhedonia. Conclusions: Lower FA in the left UF and SLF are potential neuroimaging markers of anhedonia in individuals with BD and high-risk for BD.
KW - Anhedonia
KW - Biomarker
KW - Bipolar disorders
KW - Diffusion tensor imaging
KW - Neuroimaging
KW - Nucleus accumbens
KW - Orbitofrontal cortex
KW - Humans
KW - Middle Aged
KW - Bipolar Disorder/diagnostic imaging
KW - White Matter/diagnostic imaging
KW - Anisotropy
KW - Adult
KW - Female
KW - Diffusion Tensor Imaging/methods
UR - http://www.scopus.com/inward/record.url?scp=85121902189&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85121902189&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2021.12.037
DO - 10.1016/j.jad.2021.12.037
M3 - Article
C2 - 34936916
AN - SCOPUS:85121902189
SN - 0165-0327
VL - 300
SP - 91
EP - 98
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -