Projects per year
Personal profile
Research interests
Dr. Thonhoff’s research focuses on the role of regulatory T cells (Tregs) in ALS. The loss of Treg function is associated with acceleration of disease progression in ALS. Dr. Thonhoff is exploring the mechanisms through which Treg function is lost in ALS and potential therapies aimed to enhance the neuroprotective function of Tregs. He is also investigating the use of autologous Treg infusions as a therapy for patients with ALS. In addition, he is involved in several clinical trials investigating novel treatments for patients with Myasthenia Gravis, Myotonic Dystrophy and CIDP.
Research Area Keywords
- Neurosciences
- Immunobiology & Inflammation
Free-text keywords
- Neuromuscular disorders
- Neurodegenerative diseases
- Amyotrophic Lateral Sclerosis (ALS)
- Myasthenia Gravis
- Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
- Muscular Dystrophy
- Cellular and genetic therapies
- Neuroinflammation
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Collaborations and top research areas from the last five years
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Safety and efficacy of rozanolixizumab in patients with generalised myasthenia gravis (MycarinG): a randomised, double-blind, placebo-controlled, adaptive phase 3 study
MG0003 study team, May 2023, In: The Lancet Neurology. 22, 5, p. 383-394 12 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
Adaptive Platform Trials to Transform Amyotrophic Lateral Sclerosis Therapy Development
for the Healey ALS Platform Trial Study Group, HEALEY ALS Platform Trial Study Group, Biostatisticians, Investigators, Clinical Operations Team & Medical Monitors, Feb 1 2022, In: Annals of Neurology. 91, 2, p. 165-175 11 p.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral Sclerosis
Thonhoff, J. R., Berry, J. D., Macklin, E. A., Beers, D. R., Mendoza, P. A., Zhao, W., Thome, A. D., Triolo, F., Moon, J. J., Paganoni, S., Cudkowicz, M. & Appel, S. H., Nov 29 2022, In: Neurology: Neuroimmunology and NeuroInflammation. 9, 6, e200019.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Extracellular Vesicles Derived From Ex Vivo Expanded Regulatory T Cells Modulate In Vitro and In Vivo Inflammation
Thome, A. D., Thonhoff, J. R., Zhao, W., Faridar, A., Wang, J., Beers, D. R. & Appel, S. H., Jun 22 2022, In: Frontiers in immunology. 13, p. 875825 875825.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease
Faridar, A., Vasquez, M., Thome, A. D., Yin, Z., Xuan, H., Wang, J. H., Wen, S., Li, X., Thonhoff, J. R., Zhao, W., Zhao, H., Beers, D. R., Wong, S. T. C., Masdeu, J. C. & Appel, S. H., Sep 30 2022, In: Acta Neuropathologica Communications. 10, 1, 144.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations