@article{041d5481f9794370a9553d0c8d2f3196,
title = "Acute seizure therapies in people with epilepsy: Fact or fiction? A U.S. Perspective",
abstract = "Patients with epilepsy (PWE) may experience seizure emergencies including acute repetitive seizures despite chronic treatment with daily antiseizure medications. Seizures may adversely impact routine daily activities and/or healthcare utilization and may impair the quality of life of patients with epilepsy and their caregivers. Seizures often occur at home, school, or work in a community setting. Appropriate treatment that is readily accessible for patients with seizure urgencies and emergencies is essential outside the hospital setting. When determining the best acute antiseizure therapy for PWE, clinicians need to consider all of the available rescue medications and their routes of administration including the safety and efficacy profiles. Benzodiazepines are a standard of care as a rescue therapy, yet there are several misconceptions about their use and safety. Reevaluating potential misconceptions and formulating best practices are necessary to maximize usage for each available option of acute therapy. We examine common beliefs associated with traditional use of acute seizure therapies to refute or support them based on the current level of evidence in the published literature.",
keywords = "Acute repetitive seizures, Benzodiazepines, Rescue therapy, Seizure cluster, Therapeutic misconception",
author = "Tatum, {William O.} and Tracy Glauser and Peters, {Jurriaan M.} and Amit Verma and Sarah Weatherspoon and Selim Benbadis and Becker, {Danielle A.} and Vinay Puri and Michael Smith and Misra, {Sunita N.} and Rabinowicz, {Adrian L.} and Enrique Carrazana",
note = "Funding Information: Dr Tatum received a stipend from Elsevier as immediate past Editor-in-Chief of Epilepsy & Behavior Reports and is on the Editorial Board of Journal of Clinical Neurophysiology. He has received grant funding from Eisai Inc., Martin Family Foundation, Mayo Clinic, and McElvey Fund, and industry research support from Cerevel, Engage, LivaNova, UCB and Xenon. He has served as a consultant for Bioserenity; Neurelis, Inc.; Natus and Zimmer-Biomet. He has received royalties from Demos, Springer Publishers, and Wiley. He has patents/patents pending on intraoperative monitoring devices (#62527896; #62770362). Dr Glauser is a consultant for Clarigent Health and Neurelis, Inc. He receives research support from the National Institutes of Health. Dr Peters has served as a speaker and consultant for Neurelis, Inc.; SK Life Science; and Jazz Pharmaceuticals. Dr Verma is a consultant and member of the speakers bureau for Aquestive Therapeutics; Neurelis, Inc; SK Pharmaceuticals, and UCB. Dr Weatherspoon is a consultant and speaker for Neurelis, Inc. Dr Benbadis is a consultant or member of an advisory board for Eisai Inc.; Jazz Pharmaceuticals; Neurelis, Inc; SK Life Science; Sunovion; Takeda; and UCB. He is a member of the speakers bureau for Aquestive; Eisai Inc.; Jazz Pharmaceuticals; SK Life Science; Sunovion; and UCB. Dr Becker is a consultant/speaker for Neurelis, Inc; SK Life Science; Supernus Pharmaceuticals; and UCB; is a speaker for Jazz Pharmaceuticals; and received research support from SK Life Science. Dr Puri is a consultant for Eisai Inc. and a speaker and consultant for Neurelis, Inc. Dr Smith is a consultant for Azurity Pharmaceuticals and a consultant and speaker for Neurelis, Inc., and SK Life Science. Dr Misra and Dr Rabinowicz are employees of and have received stock options from Neurelis, Inc. Dr Carrazana is an employee of and has received stock and stock options from Neurelis, Inc. Funding Information: The authors acknowledge the contributions of Tracy Dixon-Salazar, PhD, during the development of this publication. Medical writing support was provided by Laura J. Herold, MA, of The Curry Rockefeller Group, LLC (Tarrytown, NY), and was funded by Neurelis, Inc. (San Diego, CA). Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
month = jan,
doi = "10.1016/j.ebr.2023.100612",
language = "English (US)",
volume = "23",
pages = "100612",
journal = "Epilepsy and Behavior Reports",
issn = "2589-9864",
publisher = "Elsevier",
}