Clinicopathology of diffuse intrinsic pontine glioma and its redefined genomic and epigenomic landscape

Eshini Panditharatna; Kurt Yaeger; Lindsay B. Kilburn; Roger J. Packer; Javad Nazarian

doi:10.1016/j.cancergen.2015.04.008

Clinicopathology of diffuse intrinsic pontine glioma and its redefined genomic and epigenomic landscape

Eshini Panditharatna, Kurt Yaeger, Lindsay B. Kilburn, Roger J. Packer, Javad Nazarian

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Diffuse intrinsic pontine glioma (DIPG) is one of the most lethal pediatric central nervous system (CNS) cancers. Recently, a surge in molecular studies of DIPG has occurred, in large part due to the increased availability of tumor tissue through donation of post-mortem specimens. These new discoveries have established DIPGs as biologically distinct from adult gliomas, harboring unique genomic aberrations. Mutations in histone encoding genes are shown to be associated with >70% of DIPG cases. However, the exact molecular mechanisms of the tumorigenicity of these mutations remain elusive. Understanding the driving mutations and genomic landscape of DIPGs can now guide the development of targeted therapies for this incurable childhood cancer.

Original language	English (US)
Pages (from-to)	367-373
Number of pages	7
Journal	Cancer Genetics
Volume	208
Issue number	7-8
DOIs	https://doi.org/10.1016/j.cancergen.2015.04.008
State	Published - Jul 1 2015

Keywords

Brainstem glioma
Diffuse intrinsic pontine glioma
DIPG
Glioma
High grade glioma

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

Access to Document

10.1016/j.cancergen.2015.04.008

Cite this

@article{97c177695dce4373af4a3565edc85af9,

title = "Clinicopathology of diffuse intrinsic pontine glioma and its redefined genomic and epigenomic landscape",

abstract = "Diffuse intrinsic pontine glioma (DIPG) is one of the most lethal pediatric central nervous system (CNS) cancers. Recently, a surge in molecular studies of DIPG has occurred, in large part due to the increased availability of tumor tissue through donation of post-mortem specimens. These new discoveries have established DIPGs as biologically distinct from adult gliomas, harboring unique genomic aberrations. Mutations in histone encoding genes are shown to be associated with >70% of DIPG cases. However, the exact molecular mechanisms of the tumorigenicity of these mutations remain elusive. Understanding the driving mutations and genomic landscape of DIPGs can now guide the development of targeted therapies for this incurable childhood cancer.",

keywords = "Brainstem glioma, Diffuse intrinsic pontine glioma, DIPG, Glioma, High grade glioma",

author = "Eshini Panditharatna and Kurt Yaeger and Kilburn, {Lindsay B.} and Packer, {Roger J.} and Javad Nazarian",

note = "Funding Information: Funding was provided by the Smashing Walnuts Foundation (Middleburg, VA), the Zickler Family Foundation (Chevy Chase, MD), the Piedmont Community Foundation (Middleburg, VA), the Musella Foundation (Hewlett, NY); and the Brain Tumor Foundation for Children (Atlanta, GA). Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

month = jul,

day = "1",

doi = "10.1016/j.cancergen.2015.04.008",

language = "English (US)",

volume = "208",

pages = "367--373",

journal = "Cancer Genetics",

issn = "2210-7762",

publisher = "Elsevier BV",

number = "7-8",

}

TY - JOUR

T1 - Clinicopathology of diffuse intrinsic pontine glioma and its redefined genomic and epigenomic landscape

AU - Panditharatna, Eshini

AU - Yaeger, Kurt

AU - Kilburn, Lindsay B.

AU - Packer, Roger J.

AU - Nazarian, Javad

N1 - Funding Information: Funding was provided by the Smashing Walnuts Foundation (Middleburg, VA), the Zickler Family Foundation (Chevy Chase, MD), the Piedmont Community Foundation (Middleburg, VA), the Musella Foundation (Hewlett, NY); and the Brain Tumor Foundation for Children (Atlanta, GA). Publisher Copyright: © 2015 Elsevier Inc.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Diffuse intrinsic pontine glioma (DIPG) is one of the most lethal pediatric central nervous system (CNS) cancers. Recently, a surge in molecular studies of DIPG has occurred, in large part due to the increased availability of tumor tissue through donation of post-mortem specimens. These new discoveries have established DIPGs as biologically distinct from adult gliomas, harboring unique genomic aberrations. Mutations in histone encoding genes are shown to be associated with >70% of DIPG cases. However, the exact molecular mechanisms of the tumorigenicity of these mutations remain elusive. Understanding the driving mutations and genomic landscape of DIPGs can now guide the development of targeted therapies for this incurable childhood cancer.

AB - Diffuse intrinsic pontine glioma (DIPG) is one of the most lethal pediatric central nervous system (CNS) cancers. Recently, a surge in molecular studies of DIPG has occurred, in large part due to the increased availability of tumor tissue through donation of post-mortem specimens. These new discoveries have established DIPGs as biologically distinct from adult gliomas, harboring unique genomic aberrations. Mutations in histone encoding genes are shown to be associated with >70% of DIPG cases. However, the exact molecular mechanisms of the tumorigenicity of these mutations remain elusive. Understanding the driving mutations and genomic landscape of DIPGs can now guide the development of targeted therapies for this incurable childhood cancer.

KW - Brainstem glioma

KW - Diffuse intrinsic pontine glioma

KW - DIPG

KW - Glioma

KW - High grade glioma

UR - http://www.scopus.com/inward/record.url?scp=84939465355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939465355&partnerID=8YFLogxK

U2 - 10.1016/j.cancergen.2015.04.008

DO - 10.1016/j.cancergen.2015.04.008

M3 - Review article

C2 - 26206682

AN - SCOPUS:84939465355

SN - 2210-7762

VL - 208

SP - 367

EP - 373

JO - Cancer Genetics

JF - Cancer Genetics

IS - 7-8

ER -

Clinicopathology of diffuse intrinsic pontine glioma and its redefined genomic and epigenomic landscape

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this