TY - JOUR
T1 - Concise Review
T2 - Biomimetic Functionalization of Biomaterials to Stimulate the Endogenous Healing Process of Cartilage and Bone Tissue
AU - Taraballi, Francesca
AU - Bauza, Guillermo
AU - McCulloch, Patrick
AU - Harris, Josh
AU - Tasciotti, Ennio
N1 - Funding Information:
We acknowledge Kelly Hartman and Dr. Chris Tsao for their help in editing this publication. We gratefully acknowledge funding support from the following sources: the Hearst Foundation (Project ID, 18130017), the Cullen Trust for Health Care Foundation (Project ID, 18130014), and the DoD USAMRMC (Project ID, W81XWH-15-1-0718).
Funding Information:
F.T. has compensated employment. P.M. has stock options in Orthobullets.com. J.H. is a consultant Smith and Nephew, Ossur, NIA Magellan, Arthroscopy Journal and has research funding from Smith and Nephew. The other authors indicated no potential conflicts of interest.
Publisher Copyright:
© 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press
PY - 2017/12
Y1 - 2017/12
N2 - Musculoskeletal reconstruction is an ongoing challenge for surgeons as it is required for one out of five patients undergoing surgery. In the past three decades, through the close collaboration between clinicians and basic scientists, several regenerative strategies have been proposed. These have emerged from interdisciplinary approaches that bridge tissue engineering with material science, physiology, and cell biology. The paradigm behind tissue engineering is to achieve regeneration and functional recovery using stem cells, bioactive molecules, or supporting materials. Although plenty of preclinical solutions for bone and cartilage have been presented, only a few platforms have been able to move from the bench to the bedside. In this review, we highlight the limitations of musculoskeletal regeneration and summarize the most relevant acellular tissue engineering approaches. We focus on the strategies that could be most effectively translate in clinical practice and reflect on contemporary and cutting-edge regenerative strategies in surgery. Stem Cells Translational Medicine 2017;6:2186–2196.
AB - Musculoskeletal reconstruction is an ongoing challenge for surgeons as it is required for one out of five patients undergoing surgery. In the past three decades, through the close collaboration between clinicians and basic scientists, several regenerative strategies have been proposed. These have emerged from interdisciplinary approaches that bridge tissue engineering with material science, physiology, and cell biology. The paradigm behind tissue engineering is to achieve regeneration and functional recovery using stem cells, bioactive molecules, or supporting materials. Although plenty of preclinical solutions for bone and cartilage have been presented, only a few platforms have been able to move from the bench to the bedside. In this review, we highlight the limitations of musculoskeletal regeneration and summarize the most relevant acellular tissue engineering approaches. We focus on the strategies that could be most effectively translate in clinical practice and reflect on contemporary and cutting-edge regenerative strategies in surgery. Stem Cells Translational Medicine 2017;6:2186–2196.
KW - Mesenchymal stem cells
KW - Stem cell-microenvironment interactions
KW - Tissue engineering
KW - Tissue regeneration
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U2 - 10.1002/sctm.17-0181
DO - 10.1002/sctm.17-0181
M3 - Review article
C2 - 29080279
AN - SCOPUS:85035005215
SN - 2157-6564
VL - 6
SP - 2186
EP - 2196
JO - Stem Cells Translational Medicine
JF - Stem Cells Translational Medicine
IS - 12
ER -