Abstract
Background: PerR from Streptococcus pyogenes is critical for bacterial virulence. Results: We determined the crystal structure of PerR and deduced the molecular mechanism of stress sensing and gene regulation by PerR. Conclusion: A novel structural motif present at theNterminus of PerR is important for metal binding, oxidative stress sensing, and GAS virulence. Significance: The structural elements of PerR identified here could potentially be targeted for therapeutic development.
Original language | English (US) |
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Pages (from-to) | 18311-18324 |
Number of pages | 14 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 25 |
DOIs | |
State | Published - Jun 21 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology