TY - JOUR
T1 - Cytokines and acute heart failure
AU - Chen, David
AU - Assad-Kottner, Christian
AU - Orrego, Carlos
AU - Torre, Guillermo
PY - 2008/1/1
Y1 - 2008/1/1
N2 - In patients with chronic heart failure, ongoing myocardial injury partially results from activation of the inflammatory system, with production and release of proinflammatory cytokines, activation of the complement system, production of autoantibodies, overexpression of major histocompatibility complex molecules, and expression of adhesion molecules that may perpetuate the inflammatory state. Acute decompensated heart failure modifies the course of chronic heart failure and worsens outcomes via a combination of potential mechanisms, including neurohormonal activation, apoptosis, and the inflammatory cascade. Proinflammatory cytokines, including tumor necrosis factor-α and interleukin-6, play a pathogenetic role in chronic heart failure, and anti-inflammatory immune therapy is currently under investigation. In acute decompensation of chronic heart failure, the change in the inflammatory cytokine activation cascade is less clear. Larger investigational studies are needed to assess the exact roles of circulating and intracardiac cytokines in this particular patient population.
AB - In patients with chronic heart failure, ongoing myocardial injury partially results from activation of the inflammatory system, with production and release of proinflammatory cytokines, activation of the complement system, production of autoantibodies, overexpression of major histocompatibility complex molecules, and expression of adhesion molecules that may perpetuate the inflammatory state. Acute decompensated heart failure modifies the course of chronic heart failure and worsens outcomes via a combination of potential mechanisms, including neurohormonal activation, apoptosis, and the inflammatory cascade. Proinflammatory cytokines, including tumor necrosis factor-α and interleukin-6, play a pathogenetic role in chronic heart failure, and anti-inflammatory immune therapy is currently under investigation. In acute decompensation of chronic heart failure, the change in the inflammatory cytokine activation cascade is less clear. Larger investigational studies are needed to assess the exact roles of circulating and intracardiac cytokines in this particular patient population.
KW - Chronic heart failure
KW - Myocardial injury
KW - Proinflammatory cytokines
UR - http://www.scopus.com/inward/record.url?scp=37549017295&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37549017295&partnerID=8YFLogxK
U2 - 10.1097/01.CCM.0000297160.48694.90
DO - 10.1097/01.CCM.0000297160.48694.90
M3 - Article
C2 - 18158483
AN - SCOPUS:37549017295
SN - 0090-3493
VL - 36
JO - Critical Care Medicine
JF - Critical Care Medicine
IS - 1 SUPPL.
ER -