Heart transplantation and end-stage cardiac amyloidosis: a review and approach to evaluation and management.

Jerry D. Estep; Arvind Bhimaraj; A. M. Cordero-Reyes; Brian Bruckner; Matthias Loebe; Guillermo Torre-Amione

doi:10.14797/mdcj-8-3-8

Heart transplantation and end-stage cardiac amyloidosis: a review and approach to evaluation and management.

Jerry D. Estep, Arvind Bhimaraj, A. M. Cordero-Reyes, Brian Bruckner, Matthias Loebe, Guillermo Torre-Amione

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Cardiac amyloidosis is one of the most common of the infiltrative cardiomyopathies and is associated with a poor prognosis. The extent of cardiac involvement with amyloid deposition is an important determinant of treatment options and is the major determinant of outcome in patients with amyloidosis. Several small case series with sequential orthotopic heart transplantation and autologous stem cell transplant have demonstrated an improvement in post-transplant outcome and have revived enthusiasm about heart transplantation for patients with end-stage heart failure due to AL amyloidosis. The purpose of this review is to summarize the evaluation and management of cardiac amyloidosis and to provide our single-center experience with end-stage heart failure due to AL amyloidosis treated with heart transplantation followed by an autologous stem cell transplant.

Original language	English (US)
Pages (from-to)	8-16
Number of pages	9
Journal	Methodist DeBakey cardiovascular journal
Volume	8
Issue number	3
DOIs	https://doi.org/10.14797/mdcj-8-3-8
State	Published - 2012

ASJC Scopus subject areas

Medicine(all)

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title = "Heart transplantation and end-stage cardiac amyloidosis: a review and approach to evaluation and management.",

abstract = "Cardiac amyloidosis is one of the most common of the infiltrative cardiomyopathies and is associated with a poor prognosis. The extent of cardiac involvement with amyloid deposition is an important determinant of treatment options and is the major determinant of outcome in patients with amyloidosis. Several small case series with sequential orthotopic heart transplantation and autologous stem cell transplant have demonstrated an improvement in post-transplant outcome and have revived enthusiasm about heart transplantation for patients with end-stage heart failure due to AL amyloidosis. The purpose of this review is to summarize the evaluation and management of cardiac amyloidosis and to provide our single-center experience with end-stage heart failure due to AL amyloidosis treated with heart transplantation followed by an autologous stem cell transplant.",

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AU - Bruckner, Brian

AU - Loebe, Matthias

AU - Torre-Amione, Guillermo

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AB - Cardiac amyloidosis is one of the most common of the infiltrative cardiomyopathies and is associated with a poor prognosis. The extent of cardiac involvement with amyloid deposition is an important determinant of treatment options and is the major determinant of outcome in patients with amyloidosis. Several small case series with sequential orthotopic heart transplantation and autologous stem cell transplant have demonstrated an improvement in post-transplant outcome and have revived enthusiasm about heart transplantation for patients with end-stage heart failure due to AL amyloidosis. The purpose of this review is to summarize the evaluation and management of cardiac amyloidosis and to provide our single-center experience with end-stage heart failure due to AL amyloidosis treated with heart transplantation followed by an autologous stem cell transplant.

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Heart transplantation and end-stage cardiac amyloidosis: a review and approach to evaluation and management.

Abstract

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