TY - JOUR
T1 - New Frontiers in Molecular and Imaging Research on Evaluation and Diagnosis of Bladder Outlet Obstruction in Women
AU - Martinez, Laura
AU - Khavari, Rose
N1 - Funding Information:
Acknowledgements This study is supported by the National Institutes of Health Grant K12 DK0083014 and the Multidisciplinary K12 Urologic Research Career Development Program to Dolores J. Lamb from the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (RK).
Publisher Copyright:
© 2017, Springer Science+Business Media New York.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Purpose of Review: Diagnosis of bladder outlet obstruction (BOO) often presents a challenge in female patients. Traditional diagnostic elements such as symptom history and urodynamic data are rarely clear cut in women. Therefore, we sought to review the current literature on diagnosis of female BOO, focusing on new frontiers in the realm of molecular markers and imaging modalities. Recent Findings: In addition to fluoroscopy in the setting of videourodynamics, ultrasound and MRI can augment the diagnosis and aid in therapeutic planning in certain etiologies of female BOO. Furthermore, multiple potential biomarkers (i.e., nerve growth factor, prostaglandins, ATP) that have been studied in correlation to BOO in animal models as well as human subjects hold promise for diagnostic applications. Summary: These novel techniques may augment standard clinical and urodynamic evaluation of BOO in females. Future directions include further studies of each of these biomarkers in female patients with BOO compared to normal controls to test their feasibility as potential screening tools.
AB - Purpose of Review: Diagnosis of bladder outlet obstruction (BOO) often presents a challenge in female patients. Traditional diagnostic elements such as symptom history and urodynamic data are rarely clear cut in women. Therefore, we sought to review the current literature on diagnosis of female BOO, focusing on new frontiers in the realm of molecular markers and imaging modalities. Recent Findings: In addition to fluoroscopy in the setting of videourodynamics, ultrasound and MRI can augment the diagnosis and aid in therapeutic planning in certain etiologies of female BOO. Furthermore, multiple potential biomarkers (i.e., nerve growth factor, prostaglandins, ATP) that have been studied in correlation to BOO in animal models as well as human subjects hold promise for diagnostic applications. Summary: These novel techniques may augment standard clinical and urodynamic evaluation of BOO in females. Future directions include further studies of each of these biomarkers in female patients with BOO compared to normal controls to test their feasibility as potential screening tools.
KW - Biomarker
KW - Bladder outlet obstruction
KW - Diagnosis
KW - Urinary nerve growth factor
KW - Women
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U2 - 10.1007/s11884-017-0429-0
DO - 10.1007/s11884-017-0429-0
M3 - Review article
AN - SCOPUS:85036610913
SN - 1931-7212
VL - 12
SP - 291
EP - 297
JO - Current Bladder Dysfunction Reports
JF - Current Bladder Dysfunction Reports
IS - 4
ER -