TY - JOUR
T1 - Selection of mitochondria in female germline cells
T2 - is Balbiani body implicated in this process?
AU - Bilinski, Szczepan M.
AU - Kloc, Malgorzata
AU - Tworzydlo, Waclaw
N1 - Funding Information:
We are grateful to Wladyslawa Jankowska and Elzbieta Kisiel for their excellent technical support. Transmission electron (Jeol JEM 2100) and confocal (Zeiss LSM 510 Meta) microscopes were made available through the Laboratory of Microscopy, Department of Cell Biology and Imaging, Institute of Zoology and Biomedical Research of Jagiellonian University. The study was funded by a research grant K/ZDS/006317. The authors declare that they have no conflict of interest.
Publisher Copyright:
© 2017, The Author(s).
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Early oocytes of nearly all animal species contain a transient organelle assemblage termed the Balbiani body. Structure and composition of this assemblage may vary even between closely related species. Despite this variability, the Balbiani body always comprises of numerous tightly clustered mitochondria and accumulations of nuage material. It has been suggested that the Balbiani body is an evolutionarily ancestral structure, which plays a role in various processes such as the localization of organelles and macromolecules to the germ plasm, lipidogenesis, as well as the selection/elimination of dysfunctional mitochondria from female germline cells. We suggest that the selection/elimination of mitochondria is a primary and evolutionarily ancestral function of Balbiani body, and that the other functions are secondary, evolutionarily derived additions. We propose a simple model explaining the role of the Balbiani body in the selection of mitochondria, i.e., in the mitochondrial DNA (mtDNA) bottleneck phenomenon.
AB - Early oocytes of nearly all animal species contain a transient organelle assemblage termed the Balbiani body. Structure and composition of this assemblage may vary even between closely related species. Despite this variability, the Balbiani body always comprises of numerous tightly clustered mitochondria and accumulations of nuage material. It has been suggested that the Balbiani body is an evolutionarily ancestral structure, which plays a role in various processes such as the localization of organelles and macromolecules to the germ plasm, lipidogenesis, as well as the selection/elimination of dysfunctional mitochondria from female germline cells. We suggest that the selection/elimination of mitochondria is a primary and evolutionarily ancestral function of Balbiani body, and that the other functions are secondary, evolutionarily derived additions. We propose a simple model explaining the role of the Balbiani body in the selection of mitochondria, i.e., in the mitochondrial DNA (mtDNA) bottleneck phenomenon.
KW - Balbiani body
KW - Mitochondrial network
KW - Oocyte
KW - Selection of mitochondria
KW - mtDNA bottleneck
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U2 - 10.1007/s10815-017-1006-3
DO - 10.1007/s10815-017-1006-3
M3 - Review article
C2 - 28755153
AN - SCOPUS:85026480558
SN - 1058-0468
VL - 34
SP - 1405
EP - 1412
JO - Journal of Assisted Reproduction and Genetics
JF - Journal of Assisted Reproduction and Genetics
IS - 11
ER -