TY - JOUR
T1 - Sociodemographic and clinical characteristics associated with vitamin D status in newly diagnosed pediatric cancer patients
AU - Aristizabal, Paula
AU - Sherer, Michael
AU - Perdomo, Bianca P.
AU - Castelao, Esteban
AU - Thornburg, Courtney D.
AU - Proudfoot, James
AU - Jacobs, Elizabeth
AU - Newfield, Ron S.
AU - Zage, Peter
AU - Roberts, William
AU - Martinez, Maria Elena
N1 - Funding Information:
This work was supported by the National Cancer Institute K08 CA230306 (Aristizabal); the Specialized Cancer Center Support Grant to the University of California San Diego Moores Cancer Center, CA023100-29 (Martinez), the SDSU/UCSD Comprehensive Cancer Center Partnership, CA132384 and CA132379 (Martinez); NIH Grant 5T35HL007491 (Sherer); and NIH Grant UL1TR001442 (Proudfoot). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health (NIH) or National Cancer Institute (NCI). We thank Jian Shen, MS, for her biostatistics support.
Publisher Copyright:
© 2020, © 2020 Taylor & Francis Group, LLC.
PY - 2020/5/18
Y1 - 2020/5/18
N2 - Vitamin D deficiency and insufficiency are associated with serious sequelae in childhood cancer survivors. However, data on vitamin D deficiency in children with newly diagnosed cancer are scarce and the role of sociodemographic factors and vitamin D supplementation is largely unknown. We assessed vitamin D status and its socio-demographic and clinical correlates in 163 children with newly diagnosed cancer, using 25-hydroxy vitamin D (25(OH)D) concentrations and assessed longitudinal changes following vitamin D supplementation. Sixty-five percent of the patients with newly diagnosed cancer had low 25(OH)D concentrations. Fifty-two patients (32%) were vitamin D deficient (≤20 ng/mL 25(OH)D concentration), and 53(33%) were insufficient (21-29 ng/mL 25(OH)D concentration). Age over 10 (P = 0.019), Hispanic ethnicity (P = 0.002), and female sex (P = 0.008) were significantly associated with lower 25(OH)D concentration at diagnosis. Vitamin D supplementation resulted in significant increase in 25(OH)D concentrations (P < 0.001). However, following supplementation in the longitudinal analysis, this increase was less pronounced in Hispanic patients vs. non-Hispanic (P = 0.007), and in children with solid tumors vs. hematological malignancies (P = 0.003). Vitamin D deficiency and insufficiency are common in children with newly diagnosed cancer. Hispanic patients, females and older children were at higher risk for vitamin D deficiency and insufficiency. Although supplementation appeared to increase 25(OH)D concentrations over time, this increase was not as pronounced in certain subsets of patients. Prospective trials of the effects of vitamin D supplementation on bone health in children with newly diagnosed cancer are warranted, particularly in Hispanics and patients with solid tumors.
AB - Vitamin D deficiency and insufficiency are associated with serious sequelae in childhood cancer survivors. However, data on vitamin D deficiency in children with newly diagnosed cancer are scarce and the role of sociodemographic factors and vitamin D supplementation is largely unknown. We assessed vitamin D status and its socio-demographic and clinical correlates in 163 children with newly diagnosed cancer, using 25-hydroxy vitamin D (25(OH)D) concentrations and assessed longitudinal changes following vitamin D supplementation. Sixty-five percent of the patients with newly diagnosed cancer had low 25(OH)D concentrations. Fifty-two patients (32%) were vitamin D deficient (≤20 ng/mL 25(OH)D concentration), and 53(33%) were insufficient (21-29 ng/mL 25(OH)D concentration). Age over 10 (P = 0.019), Hispanic ethnicity (P = 0.002), and female sex (P = 0.008) were significantly associated with lower 25(OH)D concentration at diagnosis. Vitamin D supplementation resulted in significant increase in 25(OH)D concentrations (P < 0.001). However, following supplementation in the longitudinal analysis, this increase was less pronounced in Hispanic patients vs. non-Hispanic (P = 0.007), and in children with solid tumors vs. hematological malignancies (P = 0.003). Vitamin D deficiency and insufficiency are common in children with newly diagnosed cancer. Hispanic patients, females and older children were at higher risk for vitamin D deficiency and insufficiency. Although supplementation appeared to increase 25(OH)D concentrations over time, this increase was not as pronounced in certain subsets of patients. Prospective trials of the effects of vitamin D supplementation on bone health in children with newly diagnosed cancer are warranted, particularly in Hispanics and patients with solid tumors.
KW - Cancer disparities
KW - nutrition
KW - pediatric cancer
KW - supplementation
KW - vitamin D
UR - http://www.scopus.com/inward/record.url?scp=85081325797&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85081325797&partnerID=8YFLogxK
U2 - 10.1080/08880018.2020.1721629
DO - 10.1080/08880018.2020.1721629
M3 - Article
C2 - 32153233
AN - SCOPUS:85081325797
SN - 0888-0018
VL - 37
SP - 314
EP - 325
JO - Pediatric Hematology and Oncology
JF - Pediatric Hematology and Oncology
IS - 4
ER -