Successful Treatment of Invasive Mucormycosis in Orthotopic Liver Transplant Population

Taryn A Eubank; Constance M Mobley; Mozhgon Moaddab; Mark J Hobeika; Melissa O'Neal; William L Musick; Joshua M Knight; Joseph S Galati; Sudha Kodali; Akshay Shetty; David W Victor; Ashish Saharia; R Mark Ghobrial; Kevin A Grimes

doi:10.1155/2021/8667589

Successful Treatment of Invasive Mucormycosis in Orthotopic Liver Transplant Population

Taryn A Eubank, Constance M Mobley, Mozhgon Moaddab, Mark J Hobeika, Melissa O'Neal, William L Musick, Joshua M Knight, Joseph S Galati, Sudha Kodali, Akshay Shetty, David W Victor, Ashish Saharia, R Mark Ghobrial, Kevin A Grimes

Research output: Contribution to journal › Article › peer-review

Abstract

Mucormycosis is caused by ubiquitous fungi and encompasses a variety of different opportunistic syndromes in humans that disproportionately affect immunocompromised patients. Mortality has been documented to range between 50 and 100%; however, location of infection greatly dictates likelihood of survival. Treatment of mucormycosis involves aggressive surgical intervention and combination therapy of antifungal agents. In solid organ transplant recipients, immunosuppressive agents used to prevent rejection of the transplanted organ pose additional obstacles in the treatment of invasive fungal infections. We report on 3 high models for end-stage liver disease (MELD-Na) score orthotopic liver transplant (OLT) recipients who all were diagnosed with Rhizopus spp. infections with positive, 1-year outcomes after aggressive, individualized treatment.

Original language	English (US)
Pages (from-to)	8667589
Journal	Case reports in transplantation
Volume	2021
DOIs	https://doi.org/10.1155/2021/8667589
State	Published - 2021

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Eubank, T. A., Mobley, C. M., Moaddab, M., Hobeika, M. J., O'Neal, M., Musick, W. L., Knight, J. M., Galati, J. S., Kodali, S., Shetty, A., Victor, D. W., Saharia, A., Ghobrial, R. M., & Grimes, K. A. (2021). Successful Treatment of Invasive Mucormycosis in Orthotopic Liver Transplant Population. Case reports in transplantation, 2021, 8667589. https://doi.org/10.1155/2021/8667589

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title = "Successful Treatment of Invasive Mucormycosis in Orthotopic Liver Transplant Population",

abstract = "Mucormycosis is caused by ubiquitous fungi and encompasses a variety of different opportunistic syndromes in humans that disproportionately affect immunocompromised patients. Mortality has been documented to range between 50 and 100%; however, location of infection greatly dictates likelihood of survival. Treatment of mucormycosis involves aggressive surgical intervention and combination therapy of antifungal agents. In solid organ transplant recipients, immunosuppressive agents used to prevent rejection of the transplanted organ pose additional obstacles in the treatment of invasive fungal infections. We report on 3 high models for end-stage liver disease (MELD-Na) score orthotopic liver transplant (OLT) recipients who all were diagnosed with Rhizopus spp. infections with positive, 1-year outcomes after aggressive, individualized treatment.",

author = "Eubank, {Taryn A} and Mobley, {Constance M} and Mozhgon Moaddab and Hobeika, {Mark J} and Melissa O'Neal and Musick, {William L} and Knight, {Joshua M} and Galati, {Joseph S} and Sudha Kodali and Akshay Shetty and Victor, {David W} and Ashish Saharia and Ghobrial, {R Mark} and Grimes, {Kevin A}",

note = "Copyright {\textcopyright} 2021 Taryn A. Eubank et al.",

year = "2021",

doi = "10.1155/2021/8667589",

language = "English (US)",

volume = "2021",

pages = "8667589",

journal = "Case reports in transplantation",

issn = "2090-6943",

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TY - JOUR

T1 - Successful Treatment of Invasive Mucormycosis in Orthotopic Liver Transplant Population

AU - Eubank, Taryn A

AU - Mobley, Constance M

AU - Moaddab, Mozhgon

AU - Hobeika, Mark J

AU - O'Neal, Melissa

AU - Musick, William L

AU - Knight, Joshua M

AU - Galati, Joseph S

AU - Kodali, Sudha

AU - Shetty, Akshay

AU - Victor, David W

AU - Saharia, Ashish

AU - Ghobrial, R Mark

AU - Grimes, Kevin A

PY - 2021

Y1 - 2021

N2 - Mucormycosis is caused by ubiquitous fungi and encompasses a variety of different opportunistic syndromes in humans that disproportionately affect immunocompromised patients. Mortality has been documented to range between 50 and 100%; however, location of infection greatly dictates likelihood of survival. Treatment of mucormycosis involves aggressive surgical intervention and combination therapy of antifungal agents. In solid organ transplant recipients, immunosuppressive agents used to prevent rejection of the transplanted organ pose additional obstacles in the treatment of invasive fungal infections. We report on 3 high models for end-stage liver disease (MELD-Na) score orthotopic liver transplant (OLT) recipients who all were diagnosed with Rhizopus spp. infections with positive, 1-year outcomes after aggressive, individualized treatment.

AB - Mucormycosis is caused by ubiquitous fungi and encompasses a variety of different opportunistic syndromes in humans that disproportionately affect immunocompromised patients. Mortality has been documented to range between 50 and 100%; however, location of infection greatly dictates likelihood of survival. Treatment of mucormycosis involves aggressive surgical intervention and combination therapy of antifungal agents. In solid organ transplant recipients, immunosuppressive agents used to prevent rejection of the transplanted organ pose additional obstacles in the treatment of invasive fungal infections. We report on 3 high models for end-stage liver disease (MELD-Na) score orthotopic liver transplant (OLT) recipients who all were diagnosed with Rhizopus spp. infections with positive, 1-year outcomes after aggressive, individualized treatment.

U2 - 10.1155/2021/8667589

DO - 10.1155/2021/8667589

M3 - Article

C2 - 34912585

SN - 2090-6943

VL - 2021

SP - 8667589

JO - Case reports in transplantation

JF - Case reports in transplantation

ER -

Successful Treatment of Invasive Mucormycosis in Orthotopic Liver Transplant Population

Abstract

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