Projects per year
Personal profile
Personal profile
After receiving his Bachelor of Medicine and Bachelor of Surgery degrees from Cairo University Medical School in Cairo, Egypt, Dr. Ghobrial completed several surgical residencies in the United Kingdom and the United States. While a surgery resident at University of Texas Health Science Center in Houston, Texas, he completed a PhD in Immunology at the UT Graduate School of Biomedical Sciences in 1994. After residency, he accepted a position as clinical instructor in the Department of Surgery at the David Geffen School of Medicine at University of California, Los Angeles (UCLA) and was awarded a Dumont-UCLA Transplant Fellowship. He received his full professorship in 2005 and served as Director of the Pancreas Transplant Program and Living Donor Liver Transplantation, and Service Director for Liver, Pancreas, and Small Bowel Transplantation. He was recruited to the Houston Methodist Hospital in 2008.
Research interests
One of the primary goals of Dr. Ghobrial´s research is to increase donor tolerance to organ transplants and allografts. Dr. Ghobrial has shown in preclinical studies that tolerizing the host to dominant donor epitopes induces tolerance in the recipient. By engineering chimeric proteins, or proteins that contain sequences from both donor and recipient, and exposing the recipient to these proteins prior to tissue graft, peripheral, long-term tolerance is induced. Dr. Ghobrial also has a long-standing interest in the effects of Hepatitis (B and C) on transplantation patients.
Education/Academic qualification
Clinical Transplant , Clinical Fellowship, Dumont-UCLA Transplant Center
Jul 1 1996 → Jun 30 1998
Award Date: Jun 30 1998
General Surgery, Residency, University of Texas Health Science Center at Houston
Jul 1 1989 → Jun 30 1996
Award Date: Jun 30 1996
MD, University of Cairo Medical School
Jul 1 1975 → Jun 30 1980
Award Date: Jun 30 1980
Immunology, PhD, University of Texas Health Science Center at Houston
Research Area Keywords
- Transplantation
- Immunobiology & Inflammation
- Clinical Translation & Trials
Free-text keywords
- Liver disease
- Hepatocellular carcinoma
- Liver transplant
- Transplantation
- Liver resection
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Collaborations and top research areas from the last five years
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4/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)
8/1/23 → 7/31/30
Project: Federal Funding Agencies
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Neoadjuvant Combination Therapy of Lenvima® plus Transcatheter Arterial Chemoembolization (TACE) for Transplant-Eligible Patients with Large Hepatocellular Carcinoma
Abdelrahim, M., Connor, A. A., Ghobrial, R. M., Graviss, E. A., Heyne, K., Kodali, S., Moore, L. W., Singh, M. & Victor, III, D. W.
5/12/23 → …
Project: Clinical Trial
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A Multicenter, Prospective, Open-label, Randomized Controlled Clinical Trial to Compare the Safety and Effectiveness of the VitaSmartTM Liver Machine Perfusion System with Static Cold Storage for Organ Preservation Prior to Liver Transplantation
Saharia, A., Ghobrial, R. M., Hobeika, M. J. & Mobley, C. M.
5/16/22 → …
Project: Clinical Trial
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Bloodstream infections after solid organ transplantation: clinical epidemiology and antimicrobial resistance (2016–21)
Adelman, M. W., Connor, A. A., Hsu, E., Saharia, A., Mobley, C. M., Victor, D. W., Hobeika, M. J., Lin, J., Grimes, K. A., Ramos, E., Pedroza, C., Brombosz, E. W., Ghobrial, R. M. & Arias, C. A., Feb 1 2024, In: JAC-Antimicrobial Resistance. 6, 1, 158.Research output: Contribution to journal › Article › peer-review
Open Access -
CD4+ T cell immunity is dependent on an intrinsic stem-like program
Zou, D., Yin, Z., Yi, S. G., Wang, G., Guo, Y., Xiao, X., Li, S., Zhang, X., Gonzalez, N. M., Minze, L. J., Wang, L., Wong, S. T. C., Osama Gaber, A., Ghobrial, R. M., Li, X. C. & Chen, W., Jan 2024, In: Nature immunology. 25, 1, p. 66-76 11 p.Research output: Contribution to journal › Article › peer-review
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Degree of Discordance Between FIB-4 and Transient Elastography: An Application of Current Guidelines on General Population Cohort
Chang, M., Chang, D., Kodali, S., Harrison, S. A., Ghobrial, M., Alkhouri, N. & Noureddin, M., 2024, (Accepted/In press) In: Clinical Gastroenterology and Hepatology.Research output: Contribution to journal › Article › peer-review
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Effect of a Hispanic outreach program on referral and liver transplantation volume at a single center
Kodali, S., Mobley, C. M., Brombosz, E. W., Lopez, A., Graves, R., Ontiveros, J., Velazquez, M., Saharia, A., Cheah, Y. L., Simon, C. J., Valverde, C., Brown, A., Corkrean, J., Moore, L. W., Graviss, E. A., Victor, D. W., Maresh, K., Hobeika, M. J., Egwim, C. & Ghobrial, R. M., Jun 2024, In: Transplant Immunology. 84, 102034.Research output: Contribution to journal › Article › peer-review
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Invertebrate Immunity, Natural Transplantation Immunity, Somatic and Germ Cell Parasitism, and Transposon Defense
Kloc, M., Halasa, M., Kubiak, J. Z. & Ghobrial, R. M., Jan 2024, In: International journal of molecular sciences. 25, 2, 1072.Research output: Contribution to journal › Review article › peer-review
Open Access
Prizes
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President, International Liver Transplantation Society (ILTS)
Ghobrial, R. Mark (Recipient), Jul 1 2023
Prize: National/international honor