The promise of comparative genomics in mammals

Stephen J. O'Brien; Marilyn Menotti-Raymond; William J. Murphy; William G. Nash; Johannes Wienberg; Roscoe Stanyon; Neal G. Copeland; Nancy A. Jenkins; James E. Womack; Jennifer A. Marshall Graves

doi:10.1126/science.286.5439.458

The promise of comparative genomics in mammals

Stephen J. O'Brien, Marilyn Menotti-Raymond, William J. Murphy, William G. Nash, Johannes Wienberg, Roscoe Stanyon, Neal G. Copeland, Nancy A. Jenkins, James E. Womack, Jennifer A. Marshall Graves

Research output: Contribution to journal › Review article › peer-review

398 Scopus citations

Abstract

Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog alignment with moderate- resolution maps of livestock, companion animals, and additional mammal species. Comparative genetic assessment expands the utility of these maps in gene discovery, in functional genomics, and in tracking the evolutionary forces that sculpted the genome organization of modern mammalian species.

Original language	English (US)
Pages (from-to)	458-463
Number of pages	6
Journal	Science
Volume	286
Issue number	5439
DOIs	https://doi.org/10.1126/science.286.5439.458
State	Published - Oct 15 1999

ASJC Scopus subject areas

General

Access to Document

10.1126/science.286.5439.458

Cite this

@article{f4dd71b334d8484eb83c064ed8d73e7f,

title = "The promise of comparative genomics in mammals",

abstract = "Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog alignment with moderate- resolution maps of livestock, companion animals, and additional mammal species. Comparative genetic assessment expands the utility of these maps in gene discovery, in functional genomics, and in tracking the evolutionary forces that sculpted the genome organization of modern mammalian species.",

author = "O'Brien, {Stephen J.} and Marilyn Menotti-Raymond and Murphy, {William J.} and Nash, {William G.} and Johannes Wienberg and Roscoe Stanyon and Copeland, {Neal G.} and Jenkins, {Nancy A.} and Womack, {James E.} and {Marshall Graves}, {Jennifer A.}",

year = "1999",

month = oct,

day = "15",

doi = "10.1126/science.286.5439.458",

language = "English (US)",

volume = "286",

pages = "458--463",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5439",

}

TY - JOUR

T1 - The promise of comparative genomics in mammals

AU - O'Brien, Stephen J.

AU - Menotti-Raymond, Marilyn

AU - Murphy, William J.

AU - Nash, William G.

AU - Wienberg, Johannes

AU - Stanyon, Roscoe

AU - Copeland, Neal G.

AU - Jenkins, Nancy A.

AU - Womack, James E.

AU - Marshall Graves, Jennifer A.

PY - 1999/10/15

Y1 - 1999/10/15

N2 - Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog alignment with moderate- resolution maps of livestock, companion animals, and additional mammal species. Comparative genetic assessment expands the utility of these maps in gene discovery, in functional genomics, and in tracking the evolutionary forces that sculpted the genome organization of modern mammalian species.

AB - Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog alignment with moderate- resolution maps of livestock, companion animals, and additional mammal species. Comparative genetic assessment expands the utility of these maps in gene discovery, in functional genomics, and in tracking the evolutionary forces that sculpted the genome organization of modern mammalian species.

UR - http://www.scopus.com/inward/record.url?scp=0033569387&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033569387&partnerID=8YFLogxK

U2 - 10.1126/science.286.5439.458

DO - 10.1126/science.286.5439.458

M3 - Review article

C2 - 10521336

AN - SCOPUS:0033569387

SN - 0036-8075

VL - 286

SP - 458

EP - 463

JO - Science

JF - Science

IS - 5439

ER -

The promise of comparative genomics in mammals

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this