The promise of comparative genomics in mammals

Stephen J. O'Brien; Marilyn Menotti-Raymond; William J. Murphy; William G. Nash; Johannes Wienberg; Roscoe Stanyon; Neal G. Copeland; Nancy A. Jenkins; James E. Womack; Jennifer A. Marshall Graves

doi:10.1126/science.286.5439.458

The promise of comparative genomics in mammals

Stephen J. O'Brien, Marilyn Menotti-Raymond, William J. Murphy, William G. Nash, Johannes Wienberg, Roscoe Stanyon, Neal G. Copeland, Nancy A. Jenkins, James E. Womack, Jennifer A. Marshall Graves

Research output: Contribution to journal › Review article › peer-review

401 Scopus citations

Abstract

Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog alignment with moderate- resolution maps of livestock, companion animals, and additional mammal species. Comparative genetic assessment expands the utility of these maps in gene discovery, in functional genomics, and in tracking the evolutionary forces that sculpted the genome organization of modern mammalian species.

Original language	English (US)
Pages (from-to)	458-463
Number of pages	6
Journal	Science
Volume	286
Issue number	5439
DOIs	https://doi.org/10.1126/science.286.5439.458
State	Published - Oct 15 1999

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abstract = "Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog alignment with moderate- resolution maps of livestock, companion animals, and additional mammal species. Comparative genetic assessment expands the utility of these maps in gene discovery, in functional genomics, and in tracking the evolutionary forces that sculpted the genome organization of modern mammalian species.",

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AU - O'Brien, Stephen J.

AU - Menotti-Raymond, Marilyn

AU - Murphy, William J.

AU - Nash, William G.

AU - Wienberg, Johannes

AU - Stanyon, Roscoe

AU - Copeland, Neal G.

AU - Jenkins, Nancy A.

AU - Womack, James E.

AU - Marshall Graves, Jennifer A.

PY - 1999/10/15

Y1 - 1999/10/15

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AB - Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog alignment with moderate- resolution maps of livestock, companion animals, and additional mammal species. Comparative genetic assessment expands the utility of these maps in gene discovery, in functional genomics, and in tracking the evolutionary forces that sculpted the genome organization of modern mammalian species.

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The promise of comparative genomics in mammals

Abstract

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