Projects per year
Personal profile
Personal profile
Dr. Nancy Jenkins received her Ph.D. in molecular and cellular biology from Indiana University. Following postdoctoral studies at Harvard Medical School she joined the staff of The Jackson Laboratory and then the National Cancer Institute-Frederick, where she was a Senior Investigator and Head of the Molecular Genetics of Development Section for 22 years. She moved to the Institute of Molecular and Cell Biology in Singapore in 2006, where she served as Deputy Director for most of her stay. In 2011 she returned to the United States to serve as Co-Director of Houston Methodist Cancer Biology Program at Houston Methodist Research Institute. For more than 30 years she has co-headed a laboratory with Neal Copeland; the focus of their current research is cancer genetics. They have co-authored more than 800 papers and are among the most cited biomedical research scientists in the world today. Both have served on numerous scientific advisory and editorial boards and they have consulted for several biotechnology and pharmaceutical companies. Dr. Jenkins and Dr. Copeland are also members of the U.S. National Academy of Sciences.
Research interests
Jenkins and Copeland have modeled many different types of human disease in the mouse, but the focus of their current research is exclusively cancer. They are using the Sleeping Beauty transposable element system to tag and clone genes involved in the initiation, progression and metastasis of cancer. It is hoped that a better understanding of the genetics of cancer will lead to the development of additional targeted therapies for the treatment of various forms of the disease.
Education/Academic qualification
Viral Oncology, Postdoctoral Fellowship, Dana-Farber Cancer Institute
PhD, Indiana University, Bloomington, IN
MA, Indiana University, Bloomington, IN
Mouse Genetics, Postdoctoral Fellowship, The Jackson Laboratory
External positions
Adjunct Professor, Baylor College of Medicine
Jul 1 2013 → …
Adjunct Professor
Mar 19 2012 → …
Research Area Keywords
- Cancer
Free-text keywords
- Mouse models of cancer
- Insertional mutagenesis
- Forward genetic screens
- High throughput sequencing
- Candidate cancer gene detection
Collaborations and top research areas from the last five years
Projects
- 1 Finished
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Tumor vasculature-targeted nanotherapeutics for DNA damage response
Jenkins, N. A. (Key Personnel), Liu, X. (Key Personnel) & Mitra, S. (Key Personnel)
12/1/15 → 5/31/22
Project: Federal Funding Agencies
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Sleeping Beauty transposon mutagenesis in mouse intestinal organoids identifies genes involved in tumor progression and metastasis
Iida, N., Muranaka, Y., Park, J. W., Sekine, S., Copeland, N. G., Jenkins, N. A., Shiraishi, Y., Oshima, M. & Takeda, H., Apr 2024, In: Cancer Gene Therapy. 31, 4, p. 527-536 10 p.Research output: Contribution to journal › Article › peer-review
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TNF receptor-related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF-κB-inducing kinase-mediated hepatocyte transdifferentiation
Shiode, Y., Kodama, T., Shigeno, S., Murai, K., Tanaka, S., Newberg, J. Y., Kondo, J., Kobayashi, S., Yamada, R., Hikita, H., Sakamori, R., Suemizu, H., Tatsumi, T., Eguchi, H., Jenkins, N. A., Copeland, N. G. & Takehara, T., Feb 1 2023, In: Hepatology. 77, 2, p. 395-410 16 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Ring Finger Protein 125 Is an Anti-Proliferative Tumor Suppressor in Hepatocellular Carcinoma
Kodama, T., Kodama, M., Jenkins, N. A., Copeland, N. G., Chen, H. J. & Wei, Z., May 24 2022, In: Cancers. 14, 11, 2589.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Identification of cancer driver genes using Sleeping Beauty transposon mutagenesis
Takeda, H., Jenkins, N. A. & Copeland, N. G., Jun 2021, In: Cancer Science. 112, 6, p. 2089-2096 8 p.Research output: Contribution to journal › Review article › peer-review
Open Access6 Scopus citations -
Promoterless transposon mutagenesis drives solid cancers via tumor suppressor inactivation
Aiderus, A., Contreras-Sandoval, A. M., Meshey, A. L., Newberg, J. Y., Ward, J. M., Swing, D. A., Copeland, N. G., Jenkins, N. A., Mann, K. M. & Mann, M. B., Jan 2 2021, In: Cancers. 13, 2, p. 1-24 24 p., 225.Research output: Contribution to journal › Article › peer-review
Open Access