Projects per year
Personal profile
Personal profile
Dr. Jagannath is a medical microbiologist with an MSC degree and received his PhD degree from Jawaharlal Institute of Postgraduate Medical Education and Research, University of Madras, Pondicherry, India in 1984. He was an assistant director of infectious disease under the Ministry health, Govt of India and relocated to USA in 1990. As an instructor at the University of Illinois, Chicago, between 1991-92, he published several papers on drugs for treating multi-drug resistant tuberculosis. In 1992, he relocated to CytRX corporation Atlanta continuing TB drug research and was an adjunct Associate Professor the Emory School of Medicine. In 1996, he joined the Dept. of Pathology and laboratory medicine UTHSC Houston as an Associate Professor retired as a tenured Professor in 2018. During 20 years of research at UTHSC, he pioneered the new generation autophagy-inducing vaccines for TB and his recombinant BCG85B vaccine RESEARCH published in Nature Medicine in 2009 was profiled on NIAID website. His lab published more than 80 publications (Hi index 39; i10-index 77; >12,000 citations; Google scholar) reporting novel findings in tuberculous pathogenesis and vaccine development using mouse models. During his tenure at UTHSC-Houston, he was a teaching member for the Program in Immunology at the Graduate School Biomedical Sciences and mentored seven MS/PhD students for their degree.
Professor Jagannath is now a member of the Houston Academic Institute and a faculty at Weill Cornell Medicine. Since Jan 2019, he has established a Tuberculosis vaccine and adjuvant research laboratory at the Dept. of Pathology and Genomic medicine, HMRI, Houston. He continues his vaccine research using mice, humanized mice, and nonhuman primate models for research. His current research is on understanding and strengthening of human immune responses to infections through a Systems Biology approach using human and NHP derived immune cells and models. His lab has received near continuous NIH RO1 grant funding since 2001. He continues to serve NIH study sections and was a past empaneled member of the CSR VMD study section.
Potential for graduate student research: Ongoing research thrust includes a Systems Biology approach for macrophage and dendritic cell activation for immunotherapy of human infections; augmenting tuberculosis vaccine responses; antibody mediated immunotherapy for tuberculosis, and vaccination strategies for infants. We are currently developing new generation, intradermal and mucosal vaccines for boosting BCG vaccines against tuberculosis using mouse and NHP models.
Personal profile
We have recently developed a self - adjuvanted mRNA based tuberculosis vaccine, which has been validated for efficacy using mice. Induction of trained and adaptive immunity using new generation mRNA vaccines is our new focus of research. We have also developed a BCG -based candidate vaccine with a potential to treat bladder cancer.
External positions
Professor of Pathology and Laboratory Medicine , Weill Cornell Medical College
Mar 1 2021 → …
Research Area Keywords
- Infectious Disease & Pathology
Free-text keywords
- Tuberculosis
- Vaccines
- Human immunology
- Macrophage Biology
- Adjuvants
- Mouse models
- Innate immunity
- mRNA vaccines
- BCG based cancer vaccines
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Collaborations and top research areas from the last five years
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A novel hyper-immunogenic low virulent BCG vaccine against tuberculosis
2/3/23 → 1/31/28
Project: Federal Funding Agencies
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SigH based attenuated, efficacious Mtb vaccines to protect against lethal TB
5/1/19 → 4/30/24
Project: Federal Funding Agencies
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Role of Metabolic Me-Macrophages in the Pathogenesis of Tuberculosis during Diabetes
3/1/21 → 2/28/23
Project: Federal Funding Agencies
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Evaluation of immune responses to CD44-targeted nanovectors for designing a novel anti-tuberculosis host-directed therapy
Godin, B., Jagannath, C. & Leonard, F.
5/1/20 → 10/31/22
Project: Federal Funding Agencies
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Development of NP-Based Universal Vaccine for Influenza A Viruses
Sayedahmed, E. E., Elshafie, N. O., dos Santos, A. P., Jagannath, C., Sambhara, S. & Mittal, S. K., Feb 2024, In: Vaccines. 12, 2, 157.Research output: Contribution to journal › Article › peer-review
Open Access -
Impact of an autophagy-inducing peptide on immunogenicity and protection efficacy of an adenovirus-vectored SARS-CoV-2 vaccine
Sayedahmed, E. E., Araújo, M. V., Silva-Pereira, T. T., Chothe, S. K., Elkashif, A., Alhashimi, M., Wang, W. C., Santos, A. P., Nair, M. S., Gontu, A., Nissly, R., Francisco de Souza Filho, A., Tavares, M. S., Ayupe, M. C., Salgado, C. L., Donizetti de Oliveira Candido, É., Leal Oliveira, D. B., Durigon, E. L., Heinemann, M. B., Morais da Fonseca, D., & 4 others , Sep 14 2023, In: Molecular Therapy - Methods and Clinical Development. 30, p. 194-207 14 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Prospective Subunit Nanovaccine against Mycobacterium tuberculosis Infection─Cubosome Lipid Nanocarriers of Cord Factor, Trehalose 6,6' Dimycolate.
Sarkar, S., Mishra, A., Periasamy, S., Dyett, B., Dogra, P., Ball, A. S., Yeo, L. Y., White, J. F., Wang, Z., Cristini, V., Jagannath, C., Khan, A., Soni, S. K., Drummond, C. J. & Conn, C. E., Jun 14 2023, In: ACS Applied Materials and Interfaces. 15, 23, p. 27670-27686 17 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis
Zhang, K., Sowers, M. L., Cherryhomes, E. I., Singh, V. K., Mishra, A., Restrepo, B. I., Khan, A. & Jagannath, C., 2023, In: Frontiers in immunology. 14, p. 1121495 1121495.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Antibody-Mediated LILRB2-Receptor Antagonism Induces Human Myeloid-Derived Suppressor Cells to Kill Mycobacterium tuberculosis
Singh, V. K., Khan, A., Xu, Y., Mai, S., Zhang, L., Mishra, A., Restrepo, B. I., Pan, P. Y., Chen, S. H. & Jagannath, C., Jun 10 2022, In: Frontiers in immunology. 13, p. 865503 865503.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations