Projects per year
Personal profile
Personal profile
Kumar Pichumani, PhD, is a research scientist at the Neurosurgery Research Laboratory and Associate Research Member at Houston Methodist Research Institute. Dr. Pichumani is an NMR physicist and has worked in NMR spectroscopy since 1990. He developed new methods using first principles of NMR spin relaxation to increase both resolution and sensitivity so that complex biomacromolecules of larger molecular mass can be studied by NMR Spectroscopy. These research publications were cited by two Nobel Laureates in NMR spectroscopy.
Research interests
Dr. Pichumani's most recent research involves investigating in-vivo cancer metabolism using non- radioactive 13C enriched nutrients as infusion substrates (glucose, acetate, fatty acids), studying the fate of these substrates via high-resolution 13C NMR spectroscopy of surgically resected tumor tissues extracts. In a recent article published in CELL, he demonstrated that acetate acts as an alternate energy source for cancer cells in human glioblastoma patients and mouse models. He studied in India, Sweden and the US, gaining a diverse background spanning physics, mathematics, electronics, physical chemistry, NMR, Cancer Metabolism and biophysics.
Education/Academic qualification
Postdoctoral Fellowship, Indiana University Bloomington
… → Jun 1 2000
Award Date: Jun 1 2000
Postdoctoral Fellowship, Stockholm University
… → Jan 1 1999
Award Date: Jan 1 1999
PhD, Cross Correlations of coupled spins in NMR, Indian Institute of Science Bangalore
… → Dec 1 1997
Award Date: Dec 1 1997
Physics, MSc, Madurai Kamaraj University
… → Apr 1 1990
Award Date: Mar 31 1990
Physics and Mathematics, BSc, Madurai Kamaraj University
… → Apr 1 1988
Award Date: Mar 31 1988
Research Area Keywords
- Neurosciences
- Cancer
Free-text keywords
- Cancer metabolism
- NMR spectroscopy
- Molecular imaging
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Collaborations and top research areas from the last five years
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Targeting energy metabolism in Diffuse Intrinsic Pontine Gliomas
Pichumani, K. (PI)
7/1/24 → 6/30/27
Project: Non Profit
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Quantitation of nutrient metabolism in brain tumor patients using advanced 13C isotopomer technology
Pichumani, K. (PI)
9/1/23 → 8/31/28
Project: Federal Funding Agencies
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Administrative Supplement to Existing NIH Grant-Purchase of a Equipment
Pichumani, K. (PI)
4/1/24 → 8/31/24
Project: Federal Funding Agencies
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METHOD AND APPARATUS FOR ONCOMAGNETIC TREATMENT
Helekar, S. A. (Inventor), Baskin, D. S. (Inventor), Sharpe, M. A. (Inventor) & Pichumani, K. (Inventor), Jun 23 2022, IPC No. A61N 2/ 12 A I, Patent No. US2022193436, Priority date Dec 31 2021, Priority No. US202117567101Research output: Patent
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Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target
Abdelfattah, N., Kumar, P., Wang, C., Leu, J. S., Flynn, W. F., Gao, R., Baskin, D. S., Pichumani, K., Ijare, O. B., Wood, S. L., Powell, S. Z., Haviland, D. L., Parker Kerrigan, B. C., Lang, F. F., Prabhu, S. S., Huntoon, K. M., Jiang, W., Kim, B. Y. S., George, J. & Yun, K., Feb 9 2022, In: Nature Communications. 13, 1, p. 767 767.Research output: Contribution to journal › Article › peer-review
Open Access155 Scopus citations -
Glutamine anaplerosis is required for amino acid biosynthesis in human meningiomas
Ijare, O. B., Hambarde, S., Brasil Da Costa, F. H., Lopez, S., Sharpe, M. A., Helekar, S. A., Hangel, G., Bogner, W., Widhalm, G., Bachoo, R. M., Baskin, D. S. & Pichumani, K., Sep 13 2021, In: Neuro-oncology. 24, 4, p. 1-13 13 p., https://doi.org/10.1093/neuonc/noab219.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
METHOD AND APPARATUS FOR ONCOMAGNETIC TREATMENT
Helekar, S. A. (Inventor), Baskin, D. S. (Inventor), Sharpe, M. A. (Inventor) & Pichumani, K. (Inventor), Sep 22 2021, IPC No. A61N 2/ 12 A I, Patent No. EP3880299, Priority date Nov 13 2019, Priority No. WO2019US61131Research output: Patent
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Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells
Sharpe, M. A., Baskin, D. S., Pichumani, K., Ijare, O. B. & Helekar, S. A., Nov 10 2021, In: Frontiers in Oncology. 11, 768758.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations