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Personal profile
Personal profile
Dr. Santosh A. Helekar got his medical degree (Bachelor of Medicine and Bachelor of Surgery) from the University of Bombay in 1982. He earned a Ph.D. in Neuroscience from Baylor College of Medicine in 1991. He held faculty appointments in the Departments of Neurology and Neuroscience at Baylor College of Medicine, Department of Neurology at The Methodist Hospital Research Institute and Weill Medical College (WMC) of Cornell University before rejoining as a scientist and associate member of Houston Methodist Research Institute in 2010. Dr. Helekar is also an Associate Professor of Neurosurgery in the Academic Institute of Houston Methodist Hospital. As a member of the Research Institute Neurosciences Research Program, he directs the Magnetic Stimulation Device Core Laboratory. He is also a member of, and director of the Oncomagnetics Initiative in, the Kenneth R. Peak Center for Brain and Pituitary Tumor Treatment and Research in the Department of Neurosurgery. Presently, his primary research is focused on the development of a new noninvasive portable magnetic stimulation device called the Oncomagnetic device for use in the treatment of glioblastoma. He also conducts neuroscientific research on neuromodulation using another portable wearable device called Transcranial Rotating Permanent Magnet Stimulator (TRPMS) developed by him and Dr. Henning Voss of WMC. He also collaborates with other members of the Research Institute on TRPMS and functional magnetic resonance imaging studies in various neurological conditions. Dr. Helekar has been a member of grant review boards of the National Institutes of Health, National Science Foundation, Department of Defense and Alzheimer's Association. He has also been an E-print editor of Association for the Scientific Study of Consciousness, and a reviewer for several international research foundations and scientific journals in his fields of interest.
Research interests
Dr. Helekar's current research program focuses on the development and refinement of two new portable wearable noninvasive magnetic stimulation devices, namely an Oncomagnetic device (OMD) to treat glioblastoma and a neuromodulation device called Transcranial Rotating Permanent Magnet Stimulator (TRPMS) invented by him, the latter in collaboration with Dr. Henning Voss of WMC. Ongoing projects in his laboratory primarily involve studying the anticancer effects of OMD in cell culture, mouse models and human subjects. Other projects are focused on TRPMS stimulation using brain functional magnetic resonance imaging and electrophysiological approaches for application in basic neuroscience research and neuromodulatory therapies in neurobehavioral disorders. He is also interested in developing devices and methods inspired by theoretical ideas to conduct research related to neural processes underlying consciousness.
Education/Academic qualification
Neuroscience, PhD, In vitro Analyses of Hippocampal CA3 Pyramidal Neuronal Network Excitability Defects in an Epileptic Gene Mutation, Baylor College of Medicine
Aug 1 1986 → Jan 31 1991
Award Date: May 1 1991
Molecular Neuroscience, Postdoctoral Fellowship, The Role of Cyclophilin in the Maturation of Neuronal Nicotinic Acetylcholine Receptors , Baylor College of Medicine
Jul 1 1991 → Dec 31 1995
External positions
Adjunct Associate Professor, Baylor College of Medicine
Jul 6 2010 → Jul 5 2011
Associate Professor, Baylor College of Medicine
Mar 1 2008 → Jul 5 2010
Adjunct Associate Professor, Texas A&M University
Jun 4 2007 → …
Assistant Professor, Baylor College of Medicine
Dec 1 2002 → May 1 2005
Assistant Professor, Baylor College of Medicine
Jul 1 1996 → May 1 2005
Instructor, Baylor College of Medicine
Jan 1 1996 → Jun 30 1996
Senior Research Fellow, Department of Physiology, Goa Medical College, Bambolim, Goa
Sep 15 1985 → Jul 31 1986
Research Assistant, Department of Neurophysiology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka
Apr 1 1984 → Sep 14 1985
Research Area Keywords
- Neurosciences
Free-text keywords
- Vocal learning
- Speech and language disorders
- fMRI
- Conscious perception
- Neurophysiology
- Neuromodulation
- Motor control
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Collaborations and top research areas from the last five years
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Higher neural and clinical effects of transcranial magnetic stimulation for overactive bladder
High, R. A. (PI), Antosh, D. (Key Personnel), Gonzalez, R. (Key Personnel), Helekar, S. (Key Personnel) & Khavari, R. (Key Personnel)
1/5/24 → …
Project: Clinical Trial
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Safety, tolerability, and efficacy of TRPMS stimulation for individuals with moderate depression
Madan, A. (PI), Helekar, S. (Key Personnel), Vasquez, N. N. (Key Personnel) & Weinstein, B. (Key Personnel)
Project: Clinical Trial
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Neuromodulation by non-invasive brain magnetic stimulation in stuttering
Rosenfield, D. B. (PI) & Helekar, S. (Key Personnel)
Project: Clinical Trial
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Supraspinal mechanisms involved in neurogenic voiding dysfunction
Khavari, R. (PI), Boone, T. B. (Key Personnel), Helekar, S. (Key Personnel) & Karmonik, C. (Key Personnel)
8/1/20 → 7/31/22
Project: Federal Funding Agencies
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SUPRASPINAL TARGETS IN NEUROGENIC VOIDING DYSFUNCTION
Khavari, R. (PI), Boone, T. B. (Key Personnel), Helekar, S. (Key Personnel) & Karmonik, C. (Key Personnel)
8/17/18 → 7/31/22
Project: Federal Funding Agencies
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Evaluating noninvasive brain stimulation to treat overactive bladder in individuals with multiple sclerosis: a randomized controlled trial protocol
Salazar, B. H., Hoffman, K. A., Lincoln, J. A., Karmonik, C., Rajab, H., Helekar, S. A. & Khavari, R., Jan 25 2024, In: BMC Urology. 24, 1, p. 20 20.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells
Hambarde, S., Manalo, J. M., Baskin, D. S., Sharpe, M. A. & Helekar, S. A., Dec 2023, In: Scientific Reports. 13, 1, p. 19264 19264.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
METHOD AND APPARATUS FOR ONCOMAGNETIC TREATMENT
Helekar, S. A. (Inventor), Baskin, D. S. (Inventor), Sharpe, M. A. (Inventor) & Pichumani, K. (Inventor), Jun 23 2022, IPC No. A61N 2/ 12 A I, Patent No. US2022193436, Priority date Dec 31 2021, Priority No. US202117567101Research output: Patent
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Method for noninvasive whole-body stimulation with spinning oscillating magnetic fields and its safety in mice
Hambarde, S., Nguyen, L., Manalo, J., John, B., Baskin, D. S. & Helekar, S. A., 2022, In: Electromagnetic Biology and Medicine. 41, 4, p. 419-428 10 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Modulation of spontaneous motor unit potentials by a new motor cortical magnetic stimulation method in amyotrophic lateral sclerosis
Helekar, S. A., Thonhoff, J., John, B. S., Nguyen, L., Rosenfield, D. B. & Appel, S. H., Oct 2022, In: Journal of Neurology.Research output: Contribution to journal › Article › peer-review
Prizes
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Department of Physiology Prize
Helekar, S. (Recipient), 1978
Prize: Prize (including medals and awards)
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India Foundation Travel Scholarship Award for pursuing higher studies in the United States
Helekar, S. (Recipient), 1986
Prize: Fellowship awarded competitively
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Minoru Suzuki Award for Excellence in Neuroscience of Baylor College of Medicine
Helekar, S. (Recipient), 1990
Prize: Prize (including medals and awards)
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Southeastern Brain Tumor Foundation Award
Helekar, S. (Recipient) & Baskin, D. S. (Recipient), Oct 19 2021
Prize: Prize (including medals and awards)
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The Louis and Emma Benzak Named Postdoctoral Research Fellowship Award of the Muscular Dystrophy Association
Helekar, S. (Recipient), 1993
Prize: Fellowship awarded competitively