Research output per year
Research output per year
- 1 - 50 out of 58 results
Search results
-
2023
A phase II trial of nifurtimox combined with topotecan and cyclophosphamide for refractory or relapsed neuroblastoma and medulloblastoma
Eslin, D., Zage, P. E., Bergendahl, G., Lewis, E., Roberts, W., Kraveka, J., Mitchell, D., Isakoff, M. S., Rawwas, J., Wada, R. K., Fluchel, M., Brown, V. I., Ginn, K., Higgins, T., BeeravallyNagulapally, A., Dykema, K., Hanna, G., Ferguson, W. & Saulnier Sholler, G. L., Sep 1 2023, In: International Journal of Cancer. 153, 5, p. 1026-1034 9 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Identification of a novel gene signature for neuroblastoma differentiation using a Boolean implication network
Zage, P. E., Huo, Y., Subramonian, D., Le Clorennec, C., Ghosh, P. & Sahoo, D., Jun 2023, In: Genes Chromosomes and Cancer. 62, 6, p. 313-331 19 p.Research output: Contribution to journal › Article › peer-review
-
Targeting the RET tyrosine kinase in neuroblastoma: A review and application of a novel selective drug design strategy
Steen, E., Basilaia, M., Kim, W., Getz, T., Gustafson, J. L. & Zage, P. E., Oct 2023, In: Biochemical pharmacology. 216, p. 115751 115751.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis
Le Clorennec, C., Subramonian, D., Huo, Y. & Zage, P. E., Nov 13 2023, In: Cell Death and Disease. 14, 11, p. 739 739.Research output: Contribution to journal › Article › peer-review
Open Access -
USP7 Inhibition Suppresses Neuroblastoma Growth via Induction of p53-Mediated Apoptosis and EZH2 and N-Myc Downregulation
Le Clorennec, C., Lee, K., Huo, Y. & Zage, P. E., Sep 7 2023, In: International journal of molecular sciences. 24, 18, 13780.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2022
Allele-specific expression reveals genes with recurrent cis-regulatory alterations in high-risk neuroblastoma
Sen, A., Huo, Y., Elster, J., Zage, P. E. & McVicker, G., Mar 4 2022, In: Genome Biology. 23, 1, 71.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Genomic and Transcriptomic Analysis of Relapsed and Refractory Childhood Solid Tumors Reveals a Diverse Molecular Landscape and Mechanisms of Immune Evasion
Byron, S. A., Hendricks, W. P. D., Nagulapally, A. B., Kraveka, J. M., Ferguson, W. S., Brown, V. I., Eslin, D. E., Mitchell, D., Cornelius, A., Roberts, W., Isakoff, M. S., Oesterheld, J. E., Wada, R. K., Rawwas, J., Neville, K., Zage, P. E., Harrod, V. L., Bergendahl, G., Vansickle, E., Dykema, K., & 19 others, Dec 1 2021, In: Cancer research. 81, 23, p. 5818-5832 15 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Overview and recent advances in the targeting of medulloblastoma cancer stem cells
Paul, M. R. & Zage, P. E., 2021, In: Expert Review of Anticancer Therapy. 21, 9, p. 957-974 18 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
The anti‐tumor activity of the nedd8 inhibitor pevonedistat in neuroblastoma
Foster, J. H., Barbieri, E., Zhang, L., Scorsone, K. A., Moreno‐smith, M., Zage, P. & Horton, T. M., Jun 2 2021, In: International journal of molecular sciences. 22, 12, 6565.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2020
A subset analysis of a phase II trial evaluating the use of DFMO as maintenance therapy for high-risk neuroblastoma
Lewis, E. C., Kraveka, J. M., Ferguson, W., Eslin, D., Brown, V. I., Bergendahl, G., Roberts, W., Wada, R. K., Oesterheld, J., Mitchell, D., Foley, J., Zage, P., Rawwas, J., Rich, M., Lorenzi, E., Broglio, K., Berry, D. & Saulnier Sholler, G. L., Dec 1 2020, In: International Journal of Cancer. 147, 11, p. 3152-3159 8 p.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
Characterization of G-CSF receptor expression in medulloblastoma
Paul, M. R., Huo, Y., Liu, A., Lesperance, J., Garancher, A., Wechsler-Reya, R. J. & Zage, P. E., Jan 1 2020, In: Neuro-Oncology Advances. 2, 1, vdaa062.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Is high-risk neuroblastoma induction chemotherapy possible without G-CSF? A pilot study of safety and treatment delays in the absence of primary prophylactic hematopoietic growth factors
Whittle, S. B., Smith, V., Silverstein, A., Parmeter, M., Minard, C. G., Bernhardt, M. B., Zage, P. E., Venkatramani, R., Nuchtern, J. G., Heczey, A., Russell, H. V., Shohet, J. M. & Foster, J. H., Oct 1 2020, In: Pediatric Blood and Cancer. 67, 10, p. e28417 e28417.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Mechanisms of Efficacy of the FGFR1–3 Inhibitor AZD4547 in Pediatric Solid Tumor Models
Phanhthilath, N., Hakim, S., Su, C., Liu, A., Subramonian, D., Lesperance, J. & Zage, P. E., Dec 1 2020, In: Investigational New Drugs. 38, 6, p. 1677-1686 10 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Regorafenib is effective against neuroblastoma in vitro and in vivo and inhibits the RAS/MAPK, PI3K/Akt/mTOR and Fos/Jun pathways
Subramonian, D., Phanhthilath, N., Rinehardt, H., Flynn, S., Huo, Y., Zhang, J., Messer, K., Mo, Q., Huang, S., Lesperance, J. & Zage, P., Aug 18 2020, In: British Journal of Cancer. 123, 4, p. 568-579 12 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Sociodemographic and clinical characteristics associated with vitamin D status in newly diagnosed pediatric cancer patients
Aristizabal, P., Sherer, M., Perdomo, B. P., Castelao, E., Thornburg, C. D., Proudfoot, J., Jacobs, E., Newfield, R. S., Zage, P., Roberts, W. & Martinez, M. E., May 18 2020, In: Pediatric Hematology and Oncology. 37, 4, p. 314-325 12 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
The potential functional roles of nme1 histidine kinase activity in neuroblastoma pathogenesis
Adam, K., Lesperance, J., Hunter, T. & Zage, P. E., May 1 2020, In: International journal of molecular sciences. 21, 9, 3319.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
2019
The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo
Flynn, S. M., Lesperance, J., Macias, A., Phanhthilath, N., Paul, M. R., Kim, J. W., Tamayo, P. & Zage, P. E., 2019, In: Oncotarget. 10, 59, p. 6323-6333 11 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2018
Maintenance DFMO Increases Survival in High Risk Neuroblastoma
Sholler, G. L. S., Ferguson, W., Bergendahl, G., Bond, J. P., Neville, K., Eslin, D., Brown, V., Roberts, W., Wada, R. K., Oesterheld, J., Mitchell, D., Foley, J., Parikh, N. S., Eshun, F., Zage, P., Rawwas, J., Sencer, S., Pankiewicz, D., Quinn, M., Rich, M., & 2 others, Dec 1 2018, In: Scientific Reports. 8, 1, 14445.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations -
Novel therapies for relapsed and refractory neuroblastoma
Zage, P. E., Nov 2018, In: Children. 5, 11, 148.Research output: Contribution to journal › Review article › peer-review
Open Access41 Scopus citations -
2017
CD114: A New Member of the Neural Crest-Derived Cancer Stem Cell Marker Family
Zage, P., Whittle, S. B. & Shohet, J. M., Feb 1 2017, In: Journal of Cellular Biochemistry. 118, 2, p. 221-231 11 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Overview and recent advances in the treatment of neuroblastoma
Whittle, S. B., Smith, V., Doherty, E., Zhao, S., McCarty, S. & Zage, P., Apr 3 2017, In: Expert Review of Anticancer Therapy. 17, 4, p. 369-386 18 p.Research output: Contribution to journal › Review article › peer-review
282 Scopus citations -
2016
A polymorphism in the FGFR4 gene is associated with risk of neuroblastoma and altered receptor degradation
Whittle, S. B., Reyes, S., Du, M., Gireud, M., Zhang, L., Woodfield, S. E., Ittmann, M., Scheurer, M. E., Bean, A. J. & Zage, P., 2016, In: Journal of pediatric hematology/oncology. 38, 2, p. 131-138 8 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression
Woodfield, S. E., Zhang, L., Scorsone, K. A., Liu, Y. & Zage, P., Mar 1 2016, In: BMC Cancer. 16, 1, 172.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations -
Nifurtimox Is Effective Against Neural Tumor Cells and Is Synergistic with Buthionine Sulfoximine
Du, M., Zhang, L., Scorsone, K. A., Woodfield, S. E. & Zage, P., Jun 10 2016, In: Scientific Reports. 6, 27458.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
The novel kinase inhibitor ponatinib is an effective anti-angiogenic agent against neuroblastoma
Whittle, S. B., Patel, K., Zhang, L., Woodfield, S. E., du, M., Smith, V. & Zage, P., Dec 1 2016, In: Investigational New Drugs. 34, 6, p. 685-692 8 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
2015
CD114 expression mediates melanoma tumor cell growth and treatment resistance
Zhang, L., Agarwal, S., Shohet, J. M. & Zage, P., Jul 1 2015, In: Anticancer Research. 35, 7, p. 3787-3792 6 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
MTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling
Zhang, H., Dou, J., Yu, Y., Zhao, Y., Fan, Y., Cheng, J., Xu, X., Liu, W., Guan, S., Chen, Z., Shi, Y., Patel, R., Vasudevan, S. A., Zage, P., Zhang, H., Nuchtern, J. G., Kim, E. S., Fu, S. & Yang, J., Jan 2015, In: Apoptosis. 20, 1, p. 50-62 13 p.Research output: Contribution to journal › Article › peer-review
50 Scopus citations -
Sensitivity of neuroblastoma to the novel kinase inhibitor cabozantinib is mediated by ERK inhibition
Zhang, L., Scorsone, K., Woodfield, S. E. & Zage, P., Nov 1 2015, In: Cancer Chemotherapy and Pharmacology. 76, 5, p. 977-987 11 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
2014
Congenital neuroblastoma in a neonate with isotretinoin embryopathy
Aguilar, S., Louis, C., Hicks, J., Zage, P. & Russell, H., Mar 2014, In: Journal of pediatric hematology/oncology. 36, 2, p. e75-e77Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Etoposide-loaded immunoliposomes as active targeting agents for GD2-positive malignancies
Brown, B. S., Patanam, T., Mobli, K., Celia, C., Zage, P. E., Bean, A. J. & Tasciotti, E., Jul 2014, In: Cancer Biology and Therapy. 15, 7, p. 851-861 11 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
The novel kinase inhibitor EMD1214063 is effective against neuroblastoma
Scorsone, K., Zhang, L., Woodfield, S. E., Hicks, J. & Zage, P., Oct 2014, In: Investigational New Drugs. 32, 5, p. 815-824 10 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
UBE4B protein couples ubiquitination and sorting machineries to enable epidermal growth factor receptor (EGFR) degradation
Sirisaengtaksin, N., Gireud, M., Yan, Q., Kubota, Y., Meza, D., Waymire, J. C., Zage, P. E. & Bean, A. J., Jan 31 2014, In: Journal of Biological Chemistry. 289, 5, p. 3026-3039 14 p.Research output: Contribution to journal › Article › peer-review
40 Scopus citations -
Validation of a prognostic multi-gene signature in high-risk neuroblastoma using the high throughput digital NanoString nCounter™ system
Stricker, T. P., Morales La Madrid, A., Chlenski, A., Guerrero, L., Salwen, H. R., Gosiengfiao, Y., Perlman, E. J., Furman, W., Bahrami, A., Shohet, J. M., Zage, P. E., Hicks, M. J., Shimada, H., Suganuma, R., Park, J. R., So, S., London, W. B., Pytel, P., Maclean, K. H. & Cohn, S. L., May 2014, In: Molecular Oncology. 8, 3, p. 669-678 10 p.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
2013
UBE4B levels are correlated with clinical outcomes in neuroblastoma patients and with altered neuroblastoma cell proliferation and sensitivity to epidermal growth factor receptor inhibitors
Zage, P. E., Sirisaengtaksin, N., Liu, Y., Gireud, M., Brown, B. S., Palla, S., Richards, K. N., Hughes, D. P. M. & Bean, A. J., Feb 15 2013, In: Cancer. 119, 4, p. 915-923 9 p.Research output: Contribution to journal › Article › peer-review
31 Scopus citations -
2012
Growth factor receptor trafficking as a potential therapeutic target in pediatric cancer
Zage, P. & Bean, A. J., Feb 1 2012, In: Frontiers in Biology. 7, 1, p. 1-13 13 p.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations -
New aspects of neuroblastoma treatment: ASPHO 2011 symposium review
Zage, P., Louis, C. U. & Cohn, S. L., Jul 2012, In: Pediatric Blood and Cancer. 58, 7, p. 1099-1105 7 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
Notch pathway activation induces neuroblastoma tumor cell growth arrest
Zage, P. E., Nolo, R., Fang, W., Stewart, J., Garcia-Manero, G. & Zweidler-Mckay, P. A., May 2012, In: Pediatric Blood and Cancer. 58, 5, p. 682-689 8 p.Research output: Contribution to journal › Article › peer-review
39 Scopus citations -
Primary mediastinal neoplasms
Benveniste, M. F. K., Zage, P. E. & Erasmus, J. J., Jan 1 2012, Oncologic Imaging: A Multidisciplinary Approach. Elsevier Health Sciences, p. 63-78 16 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
-
Primary Mediastinal Neoplasms. Anatomy: Anterior mediastinal masses.
Benveniste, M. F. K., Zage, P. E. & Erasmus, J. J., Jun 22 2012, Oncologic Imaging: A Multidisciplinary Approach Expert Consult. Elsevier, p. 63-78 16 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
-
The combination of the novel glycolysis inhibitor 3-BrOP and rapamycin is effective against neuroblastoma
Levy, A. G., Zage, P. E., Akers, L. J., Ghisoli, M. L., Chen, Z., Fang, W., Kannan, S., Graham, T., Zeng, L., Franklin, A. R., Huang, P. & Zweidler-McKay, P. A., Feb 2012, In: Investigational New Drugs. 30, 1, p. 191-199 9 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Treatment of recurrent diffuse intrinsic pontine glioma: The MD Anderson Cancer Center experience
Wolff, J. E., Rytting, M. E., Vats, T. S., Zage, P. E., Ater, J. L., Woo, S., Kuttesch, J., Ketonen, L. & Mahajan, A., Jan 2012, In: Journal of Neuro-Oncology. 106, 2, p. 391-397 7 p.Research output: Contribution to journal › Article › peer-review
49 Scopus citations -
2011
Retinoic acid induces REST degradation and neuronal differentiation by modulating the expression of SCFβ-TRCP in neuroblastoma cells
Singh, A., Rokes, C., Gireud, M., Fletcher, S., Baumgartner, J., Fuller, G., Stewart, J., Zage, P. & Gopalakrishnan, V., Nov 15 2011, In: Cancer. 117, 22, p. 5189-5202 14 p.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
The selective Trk inhibitor AZ623 inhibits brain-derived neurotrophic factor-mediated neuroblastoma cell proliferation and signaling and is synergistic with topotecan
Zage, P. E., Graham, T. C., Zeng, L., Fang, W., Pien, C., Thress, K., Omer, C., Brown, J. L. & Zweidler -Mckay, P. A., Mar 15 2011, In: Cancer. 117, 6, p. 1321-1391 71 p.Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations -
2010
A novel therapeutic combination for neuroblastoma: The vascular endothelial growth factor receptor/epidermal growth factor receptor/rearranged during transfection inhibitor vandetanib with 13-cis-retinoic acid
Zage, P. E., Zeng, L., Palla, S., Fang, W., Nilsson, M. B., Heymach, J. V. & Zweidler-McKay, P. A., May 15 2010, In: Cancer. 116, 10, p. 2465-2475 11 p.Research output: Contribution to journal › Article › peer-review
25 Scopus citations -
Chromatin remodelling at the topoisomerase II-beta promoter is associated with enhanced sensitivity to etoposide in human neuroblastoma cell lines
Das, C. M., Zage, P. E., Taylor, P., Aguilera, D., Wolff, J. E. A., Lee, D. & Gopalakrishnan, V., Oct 2010, In: European Journal of Cancer. 46, 15, p. 2771-2780 10 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
Multiple receptor tyrosine kinases regulate HIF-1α and HIF-2α in normoxia and hypoxia in neuroblastoma: Implications for antiangiogenic mechanisms of multikinase inhibitors
Nilsson, M. B., Zage, P. E., Zeng, L., Xu, L., Cascone, T., Wu, H. K., Saigal, B., Zweidler-Mckay, P. A. & Heymach, J. V., May 20 2010, In: Oncogene. 29, 20, p. 2938-2949 12 p.Research output: Contribution to journal › Article › peer-review
65 Scopus citations -
Signaling of ERBB receptor tyrosine kinases promotes neuroblastoma growth in vitro and in vivo
Richards, K. N., Zweidler-McKay, P. A., Van Roy, N., Speleman, F., Trevino, J., Zage, P. E. & Hughes, D. P. M., Jul 1 2010, In: Cancer. 116, 13, p. 3233-3243 11 p.Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations -
2009
Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway
Thress, K., MacIntyre, T., Wang, H., Whitston, D., Liu, Z. Y., Hoffmann, E., Wang, T., Brown, J. L., Webster, K., Omer, C., Zage, P. E., Zeng, L. & Zweidler-McKay, P. A., Jul 1 2009, In: Molecular Cancer Therapeutics. 8, 7, p. 1818-1827 10 p.Research output: Contribution to journal › Article › peer-review
54 Scopus citations -
2008
Outcomes of a two-drug chemotherapy regimen for intraocular retinoblastoma
Zage, P. E., Reitman, A. J., Seshadri, R., Weinstein, J. L., Mets, M. B., Zeid, J. L., Greenwald, M. J., Strauss, L. C. & Goldman, S., Mar 2008, In: Pediatric Blood and Cancer. 50, 3, p. 567-572 6 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
Outcomes of the POG 9340/9341/9342 trials for children with high-risk neuroblastoma: A report from the children's oncology group
Zage, P. E., Kletzel, M., Murray, K., Marcus, R., Castleberry, R., Zhang, Y., London, W. B. & Kretschmar, C., Dec 2008, In: Pediatric Blood and Cancer. 51, 6, p. 747-753 7 p.Research output: Contribution to journal › Article › peer-review
76 Scopus citations