TY - GEN
T1 - Development of a three dimensional, multiscale agent-based model of ductal carcinoma in situ
AU - Butner, Joseph D.
AU - Cristini, Vittorio
AU - Wang, Zhihui
N1 - Publisher Copyright:
© 2017 IEEE.
PY - 2017/9/13
Y1 - 2017/9/13
N2 - Ductal carcinoma in situ (DCIS) is the most commonly diagnosed form of non-invasive breast cancer, constituting 20% of all new breast cancer cases in the United States. Although non-invasive, DCIS is usually treated surgically through resection. Interestingly, long-term survival studies have shown that patient survival rates are not significantly impacted by the type or resection, indicating that increased breast conservation through minimized surgical resection may indeed be possible. This requires a greater understanding of disease development, so that clinicians may more accurately determine surgical margins which minimize patient impact while maintaining survival rates. To this end, we have developed a three-dimensional, lattice-free multiscale agent based model of DCIS designed to help quantify ductal invasion rates, in order to allow clinicians to better estimate disease age and extent of invasion, and to predict surgical margins based on parameters obtainable from non-invasive testing (i.e., mammography). Here, we present the model development to date, and discuss some preliminary results.
AB - Ductal carcinoma in situ (DCIS) is the most commonly diagnosed form of non-invasive breast cancer, constituting 20% of all new breast cancer cases in the United States. Although non-invasive, DCIS is usually treated surgically through resection. Interestingly, long-term survival studies have shown that patient survival rates are not significantly impacted by the type or resection, indicating that increased breast conservation through minimized surgical resection may indeed be possible. This requires a greater understanding of disease development, so that clinicians may more accurately determine surgical margins which minimize patient impact while maintaining survival rates. To this end, we have developed a three-dimensional, lattice-free multiscale agent based model of DCIS designed to help quantify ductal invasion rates, in order to allow clinicians to better estimate disease age and extent of invasion, and to predict surgical margins based on parameters obtainable from non-invasive testing (i.e., mammography). Here, we present the model development to date, and discuss some preliminary results.
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U2 - 10.1109/EMBC.2017.8036769
DO - 10.1109/EMBC.2017.8036769
M3 - Conference contribution
C2 - 29059817
AN - SCOPUS:85032209888
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 86
EP - 89
BT - 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
Y2 - 11 July 2017 through 15 July 2017
ER -