Development of child immunity in the context of COVID-19 pandemic

Małgorzata Kloc; R. Mark Ghobrial; Ernest Kuchar; Sławomir Lewicki; Jacek Z. Kubiak

doi:10.1016/j.clim.2020.108510

Development of child immunity in the context of COVID-19 pandemic

Małgorzata Kloc, R. Mark Ghobrial, Ernest Kuchar, Sławomir Lewicki, Jacek Z. Kubiak

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Abstract

Children, because of having an immature immune system, are usually more prone than the adults to the microbial infections and have more severe symptoms, which is especially true for the newborns, and very young children. However, the review of clinical data from the current COVID-19 pandemic indicates otherwise. We discuss here what are the main features and components of children's immune system, the role of maternal transmission of immunity, and what are the possible explanations for the seemingly lower infection rate and severity of COVI-19 in children.

Original language	English (US)
Article number	108510
Pages (from-to)	108510
Journal	Clinical Immunology
Volume	217
DOIs	https://doi.org/10.1016/j.clim.2020.108510
State	Published - Aug 2020

Keywords

Child immunity
COVID-19
Immune system development
Macrophages
Disease Resistance
Pandemics
Age Factors
Immune System/virology
Placenta/immunology
Humans
Milk, Human/immunology
Betacoronavirus/immunology
Cytokines/immunology
Child, Preschool
Coronavirus Infections/epidemiology
Infant
Incidence
Pregnancy
Pneumonia, Viral/epidemiology
Adult
Female
Child
Infant, Newborn

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.clim.2020.108510

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title = "Development of child immunity in the context of COVID-19 pandemic",

abstract = "Children, because of having an immature immune system, are usually more prone than the adults to the microbial infections and have more severe symptoms, which is especially true for the newborns, and very young children. However, the review of clinical data from the current COVID-19 pandemic indicates otherwise. We discuss here what are the main features and components of children's immune system, the role of maternal transmission of immunity, and what are the possible explanations for the seemingly lower infection rate and severity of COVI-19 in children.",

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AU - Kloc, Małgorzata

AU - Ghobrial, R. Mark

AU - Kuchar, Ernest

AU - Lewicki, Sławomir

AU - Kubiak, Jacek Z.

PY - 2020/8

Y1 - 2020/8

N2 - Children, because of having an immature immune system, are usually more prone than the adults to the microbial infections and have more severe symptoms, which is especially true for the newborns, and very young children. However, the review of clinical data from the current COVID-19 pandemic indicates otherwise. We discuss here what are the main features and components of children's immune system, the role of maternal transmission of immunity, and what are the possible explanations for the seemingly lower infection rate and severity of COVI-19 in children.

AB - Children, because of having an immature immune system, are usually more prone than the adults to the microbial infections and have more severe symptoms, which is especially true for the newborns, and very young children. However, the review of clinical data from the current COVID-19 pandemic indicates otherwise. We discuss here what are the main features and components of children's immune system, the role of maternal transmission of immunity, and what are the possible explanations for the seemingly lower infection rate and severity of COVI-19 in children.

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KW - COVID-19

KW - Immune system development

KW - Macrophages

KW - Disease Resistance

KW - Pandemics

KW - Age Factors

KW - Immune System/virology

KW - Placenta/immunology

KW - Humans

KW - Milk, Human/immunology

KW - Betacoronavirus/immunology

KW - Cytokines/immunology

KW - Child, Preschool

KW - Coronavirus Infections/epidemiology

KW - Infant

KW - Incidence

KW - Pregnancy

KW - Pneumonia, Viral/epidemiology

KW - Adult

KW - Female

KW - Child

KW - Infant, Newborn

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ER -

Development of child immunity in the context of COVID-19 pandemic

Abstract

Keywords

ASJC Scopus subject areas

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