Emerging Lipid-Coated Silica Nanoparticles for Cancer Therapy

Achraf Noureddine; Joseph D. Butner; Wei Zhu; Paulina Naydenkov; María J. Peláez; Shreya Goel; Zhihui Wang; C. Jeffrey Brinker; Vittorio Cristini; Prashant Dogra

doi:10.1007/978-3-030-74330-7_12

Emerging Lipid-Coated Silica Nanoparticles for Cancer Therapy

Achraf Noureddine, Joseph D. Butner, Wei Zhu, Paulina Naydenkov, María J. Peláez, Shreya Goel, Zhihui Wang, C. Jeffrey Brinker, Vittorio Cristini, Prashant Dogra

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Siliceous nanomaterials are attractive candidates for applications in cancer theranostics due to their precise synthesis control, ease of surface functionalization, accuracy of characterization, controllable release of cargo, and predictable pharmacokinetics. However, the inorganic silica core inherent to these nanomaterials has colloidal instability and can be cytotoxic, presenting notable challenges for their clinical translation. Surface coatings may be used to overcome this hurdle, by improving their stability, safety, and biological activity and thereby supporting their development for various biomedical applications. Out of the various surface coatings tested to date, lipid-based coatings have shown notable potential due to their biocompatibility and low immunogenicity, where lipids have demonstrated clinical success in the form of liposomal drug delivery systems. In this chapter, we will discuss lipid-coated siliceous nanomaterials, with an emphasis on the principles of lipid coating, the enhanced biocompatibility brought about by the lipid shell, and the use of lipid-coated silica nanoparticles in cancer therapy.

Original language	English (US)
Title of host publication	Nanotechnology in the Life Sciences
Publisher	Springer Science and Business Media B.V.
Pages	335-361
Number of pages	27
DOIs	https://doi.org/10.1007/978-3-030-74330-7_12
State	Published - 2021

Publication series

Name	Nanotechnology in the Life Sciences
ISSN (Print)	2523-8027
ISSN (Electronic)	2523-8035

Keywords

Biocompatibility
Biomimetic
Cancer theranostics
Lipid coating
Mesoporous silica nanoparticles
Pharmacokinetics

ASJC Scopus subject areas

Agricultural and Biological Sciences (miscellaneous)
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Environmental Science (miscellaneous)

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10.1007/978-3-030-74330-7_12

Cite this

Noureddine, A., Butner, J. D., Zhu, W., Naydenkov, P., Peláez, M. J., Goel, S., Wang, Z., Brinker, C. J., Cristini, V., & Dogra, P. (2021). Emerging Lipid-Coated Silica Nanoparticles for Cancer Therapy. In Nanotechnology in the Life Sciences (pp. 335-361). (Nanotechnology in the Life Sciences). Springer Science and Business Media B.V.. https://doi.org/10.1007/978-3-030-74330-7_12

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abstract = "Siliceous nanomaterials are attractive candidates for applications in cancer theranostics due to their precise synthesis control, ease of surface functionalization, accuracy of characterization, controllable release of cargo, and predictable pharmacokinetics. However, the inorganic silica core inherent to these nanomaterials has colloidal instability and can be cytotoxic, presenting notable challenges for their clinical translation. Surface coatings may be used to overcome this hurdle, by improving their stability, safety, and biological activity and thereby supporting their development for various biomedical applications. Out of the various surface coatings tested to date, lipid-based coatings have shown notable potential due to their biocompatibility and low immunogenicity, where lipids have demonstrated clinical success in the form of liposomal drug delivery systems. In this chapter, we will discuss lipid-coated siliceous nanomaterials, with an emphasis on the principles of lipid coating, the enhanced biocompatibility brought about by the lipid shell, and the use of lipid-coated silica nanoparticles in cancer therapy.",

keywords = "Biocompatibility, Biomimetic, Cancer theranostics, Lipid coating, Mesoporous silica nanoparticles, Pharmacokinetics",

author = "Achraf Noureddine and Butner, {Joseph D.} and Wei Zhu and Paulina Naydenkov and Pel{\'a}ez, {Mar{\'i}a J.} and Shreya Goel and Zhihui Wang and Brinker, {C. Jeffrey} and Vittorio Cristini and Prashant Dogra",

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doi = "10.1007/978-3-030-74330-7_12",

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AU - Noureddine, Achraf

AU - Butner, Joseph D.

AU - Zhu, Wei

AU - Naydenkov, Paulina

AU - Peláez, María J.

AU - Goel, Shreya

AU - Wang, Zhihui

AU - Brinker, C. Jeffrey

AU - Cristini, Vittorio

AU - Dogra, Prashant

PY - 2021

Y1 - 2021

N2 - Siliceous nanomaterials are attractive candidates for applications in cancer theranostics due to their precise synthesis control, ease of surface functionalization, accuracy of characterization, controllable release of cargo, and predictable pharmacokinetics. However, the inorganic silica core inherent to these nanomaterials has colloidal instability and can be cytotoxic, presenting notable challenges for their clinical translation. Surface coatings may be used to overcome this hurdle, by improving their stability, safety, and biological activity and thereby supporting their development for various biomedical applications. Out of the various surface coatings tested to date, lipid-based coatings have shown notable potential due to their biocompatibility and low immunogenicity, where lipids have demonstrated clinical success in the form of liposomal drug delivery systems. In this chapter, we will discuss lipid-coated siliceous nanomaterials, with an emphasis on the principles of lipid coating, the enhanced biocompatibility brought about by the lipid shell, and the use of lipid-coated silica nanoparticles in cancer therapy.

AB - Siliceous nanomaterials are attractive candidates for applications in cancer theranostics due to their precise synthesis control, ease of surface functionalization, accuracy of characterization, controllable release of cargo, and predictable pharmacokinetics. However, the inorganic silica core inherent to these nanomaterials has colloidal instability and can be cytotoxic, presenting notable challenges for their clinical translation. Surface coatings may be used to overcome this hurdle, by improving their stability, safety, and biological activity and thereby supporting their development for various biomedical applications. Out of the various surface coatings tested to date, lipid-based coatings have shown notable potential due to their biocompatibility and low immunogenicity, where lipids have demonstrated clinical success in the form of liposomal drug delivery systems. In this chapter, we will discuss lipid-coated siliceous nanomaterials, with an emphasis on the principles of lipid coating, the enhanced biocompatibility brought about by the lipid shell, and the use of lipid-coated silica nanoparticles in cancer therapy.

KW - Biocompatibility

KW - Biomimetic

KW - Cancer theranostics

KW - Lipid coating

KW - Mesoporous silica nanoparticles

KW - Pharmacokinetics

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ER -

Emerging Lipid-Coated Silica Nanoparticles for Cancer Therapy

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