@inbook{6967ebe57e2d41aab488a3afb12e03aa,
title = "Integration of Molecular Signaling into Multiscale Modeling of Cancer",
abstract = "Multiscale modeling has now been well-accepted as a powerful tool to quantitatively represent, simulate, understand, and predict cancer progression and development across multiple biological scales. In this chapter, we focus on a specific type of multiscale cancer models where molecular signaling profiles are explicitly linked to the determination of cellular phenotypic changes. These models are particularly suitable for exploring the relationship between signaling dynamics within each individual cancer cell and the emergent cancer behavior on the multicellular level. We also discuss current challenges and future directions of this molecular signaling-incorporated multiscale cancer modeling approach.",
keywords = "Agent-based modeling, E-cadherin, Epidermal growth factor receptor, Hybrid modeling, Multiscale",
author = "Zhihui Wang and Vittorio Cristini",
note = "Publisher Copyright: {\textcopyright} 2013, Springer-Verlag Berlin Heidelberg.",
year = "2013",
doi = "10.1007/8415_2012_151",
language = "English (US)",
series = "Studies in Mechanobiology, Tissue Engineering and Biomaterials",
publisher = "Springer",
pages = "381--394",
booktitle = "Studies in Mechanobiology, Tissue Engineering and Biomaterials",
}