Investigating the Effect of Aging on the Pharmacokinetics and Tumor Delivery of Nanomaterials using Mathematical Modeling

Syed Rizvi; Akash  Awasthi; María J. Peláez; Zhihui Wang; Vittorio Cristini; Hien V. Nguyen; Prashant Dogra

doi:10.1109/EMBC44109.2020.9175322

Investigating the Effect of Aging on the Pharmacokinetics and Tumor Delivery of Nanomaterials using Mathematical Modeling

Syed Rizvi, Akash Awasthi, María J. Peláez, Zhihui Wang, Vittorio Cristini, Hien V. Nguyen, Prashant Dogra

Research output: Contribution to journal › Article

2 Scopus citations

Abstract

The application of nanomedicine for diagnosis and treatment of cancer has immense potential, but has witnessed only limited clinical success, in part due to insufficient understanding of the role of nanomaterial properties and physiological variables in governing nanoparticle (NP) pharmacology. Here, we present a multiscale mathematical model to examine the effects of physiological changes associated with patient age on the pharmacokinetics and tumor delivery efficiency of NPs. We show that physiological changes due to aging prolong the residence of NPs in the systemic circulation, thereby improving passive accumulation of NPs in tumors.Clinical Relevance - Understanding the effect of inter-individual variability on the pharmacological behavior of nanomaterials will improve their clinical translatability.

Original language	English (US)
Pages (from-to)	2447-2450
Number of pages	4
Journal	arXiv preprint arXiv:2109.14743
DOIs	https://doi.org/10.1109/EMBC44109.2020.9175322
State	Published - Jul 2020

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title = "Investigating the Effect of Aging on the Pharmacokinetics and Tumor Delivery of Nanomaterials using Mathematical Modeling",

abstract = "The application of nanomedicine for diagnosis and treatment of cancer has immense potential, but has witnessed only limited clinical success, in part due to insufficient understanding of the role of nanomaterial properties and physiological variables in governing nanoparticle (NP) pharmacology. Here, we present a multiscale mathematical model to examine the effects of physiological changes associated with patient age on the pharmacokinetics and tumor delivery efficiency of NPs. We show that physiological changes due to aging prolong the residence of NPs in the systemic circulation, thereby improving passive accumulation of NPs in tumors.Clinical Relevance - Understanding the effect of inter-individual variability on the pharmacological behavior of nanomaterials will improve their clinical translatability.",

author = "Syed Rizvi and Akash Awasthi and Pel{\'a}ez, {Mar{\'i}a J.} and Zhihui Wang and Vittorio Cristini and Nguyen, {Hien V.} and Prashant Dogra",

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AU - Rizvi, Syed

AU - Awasthi, Akash

AU - Peláez, María J.

AU - Wang, Zhihui

AU - Cristini, Vittorio

AU - Nguyen, Hien V.

AU - Dogra, Prashant

PY - 2020/7

Y1 - 2020/7

N2 - The application of nanomedicine for diagnosis and treatment of cancer has immense potential, but has witnessed only limited clinical success, in part due to insufficient understanding of the role of nanomaterial properties and physiological variables in governing nanoparticle (NP) pharmacology. Here, we present a multiscale mathematical model to examine the effects of physiological changes associated with patient age on the pharmacokinetics and tumor delivery efficiency of NPs. We show that physiological changes due to aging prolong the residence of NPs in the systemic circulation, thereby improving passive accumulation of NPs in tumors.Clinical Relevance - Understanding the effect of inter-individual variability on the pharmacological behavior of nanomaterials will improve their clinical translatability.

AB - The application of nanomedicine for diagnosis and treatment of cancer has immense potential, but has witnessed only limited clinical success, in part due to insufficient understanding of the role of nanomaterial properties and physiological variables in governing nanoparticle (NP) pharmacology. Here, we present a multiscale mathematical model to examine the effects of physiological changes associated with patient age on the pharmacokinetics and tumor delivery efficiency of NPs. We show that physiological changes due to aging prolong the residence of NPs in the systemic circulation, thereby improving passive accumulation of NPs in tumors.Clinical Relevance - Understanding the effect of inter-individual variability on the pharmacological behavior of nanomaterials will improve their clinical translatability.

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JO - arXiv preprint arXiv:2109.14743

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Investigating the Effect of Aging on the Pharmacokinetics and Tumor Delivery of Nanomaterials using Mathematical Modeling

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