Macrophage functions in wound healing

Malgorzata Kloc; R. Mark Ghobrial; Jarek Wosik; Aneta Lewicka; Sławomir Lewicki; Jacek Z. Kubiak

doi:10.1002/term.2772

Macrophage functions in wound healing

Malgorzata Kloc, R. Mark Ghobrial, Jarek Wosik, Aneta Lewicka, Sławomir Lewicki, Jacek Z. Kubiak

Research output: Contribution to journal › Review article › peer-review

83 Scopus citations

Abstract

Macrophages play a crucial role in regeneration and consecutive phases of wound healing. In this review, we summarise current knowledge on the ontogeny, origin, phenotypical heterogeneity, and functional exchangeability of macrophages participating in these processes. We also describe the genetic, pharmacologic, and bioengineering methods for manipulation of macrophage phenotype and functions and their potential for development of the novel, clinically applicable therapies.

Original language	English (US)
Pages (from-to)	99-109
Number of pages	11
Journal	Journal of Tissue Engineering and Regenerative Medicine
Volume	13
Issue number	1
Early online date	Jan 2019
DOIs	https://doi.org/10.1002/term.2772
State	E-pub ahead of print - Jan 2019

Keywords

CX3CR1
ROCK kinase
RhoAactin
macrophages
wound healing

ASJC Scopus subject areas

Medicine (miscellaneous)
Biomaterials
Biomedical Engineering

Access to Document

10.1002/term.2772

Cite this

@article{3c08ecefca6345a88deceb3749fcf49a,

title = "Macrophage functions in wound healing",

abstract = "Macrophages play a crucial role in regeneration and consecutive phases of wound healing. In this review, we summarise current knowledge on the ontogeny, origin, phenotypical heterogeneity, and functional exchangeability of macrophages participating in these processes. We also describe the genetic, pharmacologic, and bioengineering methods for manipulation of macrophage phenotype and functions and their potential for development of the novel, clinically applicable therapies.",

keywords = "CX3CR1, ROCK kinase, RhoAactin, macrophages, wound healing",

author = "Malgorzata Kloc and Ghobrial, {R. Mark} and Jarek Wosik and Aneta Lewicka and S{\l}awomir Lewicki and Kubiak, {Jacek Z.}",

note = "Funding Information: We are grateful for the support from William Stamps Farish Fund, Polish Ministry of National Defense project “Ko{\'s}ciuszko” #571/2016/DA to JZK, and Polish Ministry of National Defense project “Ko{\'s}ciuszko” #5508/2017/DA to JZK. Publisher Copyright: {\textcopyright} 2018 John Wiley & Sons, Ltd.",

year = "2019",

month = jan,

doi = "10.1002/term.2772",

language = "English (US)",

volume = "13",

pages = "99--109",

journal = "Journal of Tissue Engineering and Regenerative Medicine",

issn = "1932-6254",

publisher = "Wiley",

number = "1",

}

TY - JOUR

T1 - Macrophage functions in wound healing

AU - Kloc, Malgorzata

AU - Ghobrial, R. Mark

AU - Wosik, Jarek

AU - Lewicka, Aneta

AU - Lewicki, Sławomir

AU - Kubiak, Jacek Z.

N1 - Funding Information: We are grateful for the support from William Stamps Farish Fund, Polish Ministry of National Defense project “Kościuszko” #571/2016/DA to JZK, and Polish Ministry of National Defense project “Kościuszko” #5508/2017/DA to JZK. Publisher Copyright: © 2018 John Wiley & Sons, Ltd.

PY - 2019/1

Y1 - 2019/1

N2 - Macrophages play a crucial role in regeneration and consecutive phases of wound healing. In this review, we summarise current knowledge on the ontogeny, origin, phenotypical heterogeneity, and functional exchangeability of macrophages participating in these processes. We also describe the genetic, pharmacologic, and bioengineering methods for manipulation of macrophage phenotype and functions and their potential for development of the novel, clinically applicable therapies.

AB - Macrophages play a crucial role in regeneration and consecutive phases of wound healing. In this review, we summarise current knowledge on the ontogeny, origin, phenotypical heterogeneity, and functional exchangeability of macrophages participating in these processes. We also describe the genetic, pharmacologic, and bioengineering methods for manipulation of macrophage phenotype and functions and their potential for development of the novel, clinically applicable therapies.

KW - CX3CR1

KW - ROCK kinase

KW - RhoAactin

KW - macrophages

KW - wound healing

UR - http://www.scopus.com/inward/record.url?scp=85058384095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058384095&partnerID=8YFLogxK

U2 - 10.1002/term.2772

DO - 10.1002/term.2772

M3 - Review article

C2 - 30445662

AN - SCOPUS:85058384095

SN - 1932-6254

VL - 13

SP - 99

EP - 109

JO - Journal of Tissue Engineering and Regenerative Medicine

JF - Journal of Tissue Engineering and Regenerative Medicine

IS - 1

ER -

Macrophage functions in wound healing

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this