Macrophage phenotype bioengineered by magnetic, genetic, or pharmacologic interference

Jarek Wosik; Martha Suarez-Villagran; John H. Miller; R. Mark Ghobrial; Malgorzata Kloc

doi:10.1007/s12026-019-9066-3

Macrophage phenotype bioengineered by magnetic, genetic, or pharmacologic interference

Jarek Wosik, Martha Suarez-Villagran, John H. Miller, R. Mark Ghobrial, Malgorzata Kloc

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

In all eukaryotes, the cell shape depends on the actin filament cytoskeleton, which is regulated by the small GTPase RhoA. It is well known that the cell shape determines cell function and behavior. Inversely, any change in the cell behavior and/or function reverberates at the cell shape. In this review, we describe how mechanical/magnetic, genetic, or pharmacologic interference with the actin cytoskeleton enforces changes in cell shape and function and how such techniques can be used to control the phenotype and functions of immune cells such as macrophages and to develop novel anti-cancer and anti-rejection clinical therapies.

Original language	English (US)
Pages (from-to)	1-11
Number of pages	11
Journal	Immunologic Research
Volume	67
Issue number	1
DOIs	https://doi.org/10.1007/s12026-019-9066-3
State	Published - Feb 2019

Keywords

Actin
Cancer
Macrophage
Magnetic field
RhoA
Transplantation

ASJC Scopus subject areas

Immunology

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10.1007/s12026-019-9066-3

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title = "Macrophage phenotype bioengineered by magnetic, genetic, or pharmacologic interference",

abstract = "In all eukaryotes, the cell shape depends on the actin filament cytoskeleton, which is regulated by the small GTPase RhoA. It is well known that the cell shape determines cell function and behavior. Inversely, any change in the cell behavior and/or function reverberates at the cell shape. In this review, we describe how mechanical/magnetic, genetic, or pharmacologic interference with the actin cytoskeleton enforces changes in cell shape and function and how such techniques can be used to control the phenotype and functions of immune cells such as macrophages and to develop novel anti-cancer and anti-rejection clinical therapies.",

keywords = "Actin, Cancer, Macrophage, Magnetic field, RhoA, Transplantation",

author = "Jarek Wosik and Martha Suarez-Villagran and Miller, {John H.} and Ghobrial, {R. Mark} and Malgorzata Kloc",

note = "Funding Information: Acknowledgments The authors gratefully acknowledge the support from the William and Ella Owens Medical Research Foundation, the William Stamps Farish Fund, and the State of Texas through the Texas Center for Superconductivity at the University of Houston. Publisher Copyright: {\textcopyright} 2019, Springer Science+Business Media, LLC, part of Springer Nature.",

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AU - Suarez-Villagran, Martha

AU - Miller, John H.

AU - Ghobrial, R. Mark

AU - Kloc, Malgorzata

N1 - Funding Information: Acknowledgments The authors gratefully acknowledge the support from the William and Ella Owens Medical Research Foundation, the William Stamps Farish Fund, and the State of Texas through the Texas Center for Superconductivity at the University of Houston. Publisher Copyright: © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2019/2

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N2 - In all eukaryotes, the cell shape depends on the actin filament cytoskeleton, which is regulated by the small GTPase RhoA. It is well known that the cell shape determines cell function and behavior. Inversely, any change in the cell behavior and/or function reverberates at the cell shape. In this review, we describe how mechanical/magnetic, genetic, or pharmacologic interference with the actin cytoskeleton enforces changes in cell shape and function and how such techniques can be used to control the phenotype and functions of immune cells such as macrophages and to develop novel anti-cancer and anti-rejection clinical therapies.

AB - In all eukaryotes, the cell shape depends on the actin filament cytoskeleton, which is regulated by the small GTPase RhoA. It is well known that the cell shape determines cell function and behavior. Inversely, any change in the cell behavior and/or function reverberates at the cell shape. In this review, we describe how mechanical/magnetic, genetic, or pharmacologic interference with the actin cytoskeleton enforces changes in cell shape and function and how such techniques can be used to control the phenotype and functions of immune cells such as macrophages and to develop novel anti-cancer and anti-rejection clinical therapies.

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KW - Cancer

KW - Macrophage

KW - Magnetic field

KW - RhoA

KW - Transplantation

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Macrophage phenotype bioengineered by magnetic, genetic, or pharmacologic interference

Abstract

Keywords

ASJC Scopus subject areas

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