@inbook{308f3bc0ef3f4dc7bf02cbc32b0dcd8d,
title = "Macrophages and RhoA Pathway in Transplanted Organs",
abstract = "RhoA is a small GTPase that, via its downstream effectors, regulates a variety of cell functions such as cytokinesis, cell migration, vesicular trafficking, and phagocytosis. As such the RhoA pathway is also pivotal for proper functioning of immune cells including macrophages. By controlling actin cytoskeleton organization, RhoA pathway modulates macrophage{\textquoteright}s polarity and basic functions: phagocytosis, migration, and extracellular matrix degradation. Numerous studies indicate that macrophages are very important effectors contributing to acute and chronic rejection of transplanted organs. In this review we discuss the role of RhoA pathway in governance of macrophage{\textquoteright}s functions in terms of transplanted organs.",
author = "Yianzhu Liu and Kubiak, {Jacek Z.} and Li, {Xian C.} and Ghobrial, {Rafik M.} and Malgorzata Kloc",
note = "Funding Information: We are grateful for the support from William Stamps Farish Fund and Donald D. Hammill Foundation. Publisher Copyright: {\textcopyright} Springer International Publishing AG 2017. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
year = "2017",
month = apr,
day = "29",
doi = "10.1007/978-3-319-54090-0_15",
language = "English (US)",
volume = "62",
series = "Results and Problems in Cell Differentiation",
publisher = "Springer-Verlag",
pages = "365--376",
booktitle = "Results and Problems in Cell Differentiation",
}