TY - JOUR
T1 - Mechanistic modeling for optimal design of dissolvable microneedle-based patches for transdermal drug delivery
AU - Pelaez, Maria J
AU - Ruiz-Ramirez, Javier
AU - Shen, Yu
AU - Birur, Ruchi M
AU - Schiavone, Carmine
AU - Cristini, Vittorio
AU - Puri, Ashana
AU - Wang, Zhihui
AU - Dogra, Prashant
PY - 2023/7/1
Y1 - 2023/7/1
N2 - Polymeric microneedle (MN)-based patches are an efficient, non-invasive, and painless means of drug delivery through the skin to systemic circulation. The design of these MN-based patches can be customized for various drug delivery applications, particularly modified release of drugs. In this study, we developed a mathematical model of drug delivery via MN-based patches to study the effect of patch design properties on drug delivery kinetics and systemic pharmacokinetics (PK). We calibrated the model against two representative formulations: a rapid release patch of naloxone and a sustained-release patch of levonorgestrel. The model was then applied to assess the relative significance of model parameters in governing systemic PK of drugs and obtain optimal design parameters to achieve therapeutically meaningful drug levels in a clinical setting. We identified the importance of drug loading fraction, MN base radius, and MN height as the key control parameters responsible for drug PK.Clinical Relevance- Through the application of modeling and simulation, we can improve drug delivery from MN-based patches by identifying optimal design parameters to support the clinical translation of these novel drug delivery systems.
AB - Polymeric microneedle (MN)-based patches are an efficient, non-invasive, and painless means of drug delivery through the skin to systemic circulation. The design of these MN-based patches can be customized for various drug delivery applications, particularly modified release of drugs. In this study, we developed a mathematical model of drug delivery via MN-based patches to study the effect of patch design properties on drug delivery kinetics and systemic pharmacokinetics (PK). We calibrated the model against two representative formulations: a rapid release patch of naloxone and a sustained-release patch of levonorgestrel. The model was then applied to assess the relative significance of model parameters in governing systemic PK of drugs and obtain optimal design parameters to achieve therapeutically meaningful drug levels in a clinical setting. We identified the importance of drug loading fraction, MN base radius, and MN height as the key control parameters responsible for drug PK.Clinical Relevance- Through the application of modeling and simulation, we can improve drug delivery from MN-based patches by identifying optimal design parameters to support the clinical translation of these novel drug delivery systems.
KW - Needles
KW - Microinjections
KW - Administration, Cutaneous
KW - Skin
KW - Pharmaceutical Preparations
KW - Drug Delivery Systems
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UR - http://www.scopus.com/inward/citedby.url?scp=85179640914&partnerID=8YFLogxK
U2 - 10.1109/EMBC40787.2023.10341093
DO - 10.1109/EMBC40787.2023.10341093
M3 - Article
C2 - 38082979
SN - 2375-7477
VL - 2023
SP - 1
EP - 4
JO - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
JF - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
ER -