Monocyte–Macrophage Lineage Cell Fusion

Malgorzata Kloc; Arijita Subuddhi; Ahmed Uosef; Jacek Z. Kubiak; Rafik M. Ghobrial

doi:10.3390/ijms23126553

Monocyte–Macrophage Lineage Cell Fusion

Malgorzata Kloc, Arijita Subuddhi, Ahmed Uosef, Jacek Z. Kubiak, Rafik M. Ghobrial

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Cell fusion (fusogenesis) occurs in natural and pathological conditions in prokaryotes and eukaryotes. Cells of monocyte–macrophage lineage are highly fusogenic. They create syncytial multinucleated giant cells (MGCs) such as osteoclasts (OCs), MGCs associated with the areas of infection/inflammation, and foreign body-induced giant cells (FBGCs). The fusion of monocytes/macrophages with tumor cells may promote cancer metastasis. We describe types and examples of monocyte–macrophage lineage cell fusion and the role of actin-based structures in cell fusion.

Original language	English (US)
Article number	6553
Journal	International journal of molecular sciences
Volume	23
Issue number	12
DOIs	https://doi.org/10.3390/ijms23126553
State	Published - Jun 12 2022

Keywords

cell fusion
cell protrusions
giant cells
hematopoietic stem cells
macrophage
monocyte
osteoclast
podosomes
syncytium
tumor-associated macrophages
viral fusion
Osteoclasts/metabolism
Giant Cells, Foreign-Body/metabolism
Cell Fusion
Cell Differentiation
Giant Cells/pathology
Monocytes/metabolism

ASJC Scopus subject areas

Molecular Biology
Spectroscopy
Catalysis
Inorganic Chemistry
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/ijms23126553

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title = "Monocyte–Macrophage Lineage Cell Fusion",

abstract = "Cell fusion (fusogenesis) occurs in natural and pathological conditions in prokaryotes and eukaryotes. Cells of monocyte–macrophage lineage are highly fusogenic. They create syncytial multinucleated giant cells (MGCs) such as osteoclasts (OCs), MGCs associated with the areas of infection/inflammation, and foreign body-induced giant cells (FBGCs). The fusion of monocytes/macrophages with tumor cells may promote cancer metastasis. We describe types and examples of monocyte–macrophage lineage cell fusion and the role of actin-based structures in cell fusion.",

keywords = "cell fusion, cell protrusions, giant cells, hematopoietic stem cells, macrophage, monocyte, osteoclast, podosomes, syncytium, tumor-associated macrophages, viral fusion, Osteoclasts/metabolism, Giant Cells, Foreign-Body/metabolism, Cell Fusion, Cell Differentiation, Giant Cells/pathology, Monocytes/metabolism",

author = "Malgorzata Kloc and Arijita Subuddhi and Ahmed Uosef and Kubiak, {Jacek Z.} and Ghobrial, {Rafik M.}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jun,

day = "12",

doi = "10.3390/ijms23126553",

language = "English (US)",

volume = "23",

journal = "International journal of molecular sciences",

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number = "12",

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TY - JOUR

T1 - Monocyte–Macrophage Lineage Cell Fusion

AU - Kloc, Malgorzata

AU - Subuddhi, Arijita

AU - Uosef, Ahmed

AU - Kubiak, Jacek Z.

AU - Ghobrial, Rafik M.

PY - 2022/6/12

Y1 - 2022/6/12

N2 - Cell fusion (fusogenesis) occurs in natural and pathological conditions in prokaryotes and eukaryotes. Cells of monocyte–macrophage lineage are highly fusogenic. They create syncytial multinucleated giant cells (MGCs) such as osteoclasts (OCs), MGCs associated with the areas of infection/inflammation, and foreign body-induced giant cells (FBGCs). The fusion of monocytes/macrophages with tumor cells may promote cancer metastasis. We describe types and examples of monocyte–macrophage lineage cell fusion and the role of actin-based structures in cell fusion.

AB - Cell fusion (fusogenesis) occurs in natural and pathological conditions in prokaryotes and eukaryotes. Cells of monocyte–macrophage lineage are highly fusogenic. They create syncytial multinucleated giant cells (MGCs) such as osteoclasts (OCs), MGCs associated with the areas of infection/inflammation, and foreign body-induced giant cells (FBGCs). The fusion of monocytes/macrophages with tumor cells may promote cancer metastasis. We describe types and examples of monocyte–macrophage lineage cell fusion and the role of actin-based structures in cell fusion.

KW - cell fusion

KW - cell protrusions

KW - giant cells

KW - hematopoietic stem cells

KW - macrophage

KW - monocyte

KW - osteoclast

KW - podosomes

KW - syncytium

KW - tumor-associated macrophages

KW - viral fusion

KW - Osteoclasts/metabolism

KW - Giant Cells, Foreign-Body/metabolism

KW - Cell Fusion

KW - Cell Differentiation

KW - Giant Cells/pathology

KW - Monocytes/metabolism

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U2 - 10.3390/ijms23126553

DO - 10.3390/ijms23126553

M3 - Review article

C2 - 35742997

AN - SCOPUS:85131663950

SN - 1661-6596

VL - 23

JO - International journal of molecular sciences

JF - International journal of molecular sciences

IS - 12

M1 - 6553

ER -

Monocyte–Macrophage Lineage Cell Fusion

Abstract

Keywords

ASJC Scopus subject areas

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