Natural genetic engineering: A programmed chromosome/DNA elimination

Malgorzata Kloc; Jacek Z. Kubiak; Rafik M. Ghobrial

doi:10.1016/j.ydbio.2022.03.008

Natural genetic engineering: A programmed chromosome/DNA elimination

Malgorzata Kloc, Jacek Z. Kubiak, Rafik M. Ghobrial

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Typically, all cells of a given organism have the same set of chromosomes. However, there are exceptions to this rule, and in many organisms, the somatic cells and germ cells, various types of somatic cells or organs, or females and males, have different genomes. One of the sources of such differences is chromosome/DNA elimination/chromatin diminution that is a naturally programmed phenomenon. We describe chromosome/DNA elimination in various organisms and present the current hypotheses on its origin, mechanisms, significance, and consequences.

Original language	English (US)
Pages (from-to)	15-25
Number of pages	11
Journal	Developmental Biology
Volume	486
DOIs	https://doi.org/10.1016/j.ydbio.2022.03.008
State	Published - Jun 2022

Keywords

B chromosomes
Chromosome drive
Chromosome elimination
Diminution
Gene silencing
Programmed DNA elimination
Repetitive sequences
Super-mendelian inheritance
Chromatin
Humans
Male
DNA/genetics
Genetic Engineering
Genome/genetics
Female
Chromosomes

ASJC Scopus subject areas

Molecular Biology
Cell Biology
Developmental Biology

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10.1016/j.ydbio.2022.03.008

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@article{89a68256aafb47309c11cad2344a924d,

title = "Natural genetic engineering: A programmed chromosome/DNA elimination",

abstract = "Typically, all cells of a given organism have the same set of chromosomes. However, there are exceptions to this rule, and in many organisms, the somatic cells and germ cells, various types of somatic cells or organs, or females and males, have different genomes. One of the sources of such differences is chromosome/DNA elimination/chromatin diminution that is a naturally programmed phenomenon. We describe chromosome/DNA elimination in various organisms and present the current hypotheses on its origin, mechanisms, significance, and consequences.",

keywords = "B chromosomes, Chromosome drive, Chromosome elimination, Diminution, Gene silencing, Programmed DNA elimination, Repetitive sequences, Super-mendelian inheritance, Chromatin, Humans, Male, DNA/genetics, Genetic Engineering, Genome/genetics, Female, Chromosomes",

author = "Malgorzata Kloc and Kubiak, {Jacek Z.} and Ghobrial, {Rafik M.}",

note = "Funding Information: M. Kloc dedicates this paper to the memory of Prof. Kraczkiewicz who studied chromosome elimination in the gall midge (Cecidomyiidae) insects at Warsaw University in Poland from 1935 until his passing in 1971. Prof. Kraczkiewicz was Dr. Kloc's first mentor of cell biology at the University of Warsaw, Poland. The images of oocytes he showed during his lectures sparked Dr. Kloc's life-long fascination with oocytes and germ cell determination. She will always remember Professor Kraczkiewicz with a great fondness and gratitude for focusing her love of biology on these enchanting subjects. We also acknowledge that some of the drawings used to make figures were from the Servier Medical ART: SMART, smart.servier.com. Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = jun,

doi = "10.1016/j.ydbio.2022.03.008",

language = "English (US)",

volume = "486",

pages = "15--25",

journal = "Developmental Biology",

issn = "0012-1606",

publisher = "Academic Press",

}

TY - JOUR

T1 - Natural genetic engineering

T2 - A programmed chromosome/DNA elimination

AU - Kloc, Malgorzata

AU - Kubiak, Jacek Z.

AU - Ghobrial, Rafik M.

N1 - Funding Information: M. Kloc dedicates this paper to the memory of Prof. Kraczkiewicz who studied chromosome elimination in the gall midge (Cecidomyiidae) insects at Warsaw University in Poland from 1935 until his passing in 1971. Prof. Kraczkiewicz was Dr. Kloc's first mentor of cell biology at the University of Warsaw, Poland. The images of oocytes he showed during his lectures sparked Dr. Kloc's life-long fascination with oocytes and germ cell determination. She will always remember Professor Kraczkiewicz with a great fondness and gratitude for focusing her love of biology on these enchanting subjects. We also acknowledge that some of the drawings used to make figures were from the Servier Medical ART: SMART, smart.servier.com. Publisher Copyright: © 2022

PY - 2022/6

Y1 - 2022/6

N2 - Typically, all cells of a given organism have the same set of chromosomes. However, there are exceptions to this rule, and in many organisms, the somatic cells and germ cells, various types of somatic cells or organs, or females and males, have different genomes. One of the sources of such differences is chromosome/DNA elimination/chromatin diminution that is a naturally programmed phenomenon. We describe chromosome/DNA elimination in various organisms and present the current hypotheses on its origin, mechanisms, significance, and consequences.

AB - Typically, all cells of a given organism have the same set of chromosomes. However, there are exceptions to this rule, and in many organisms, the somatic cells and germ cells, various types of somatic cells or organs, or females and males, have different genomes. One of the sources of such differences is chromosome/DNA elimination/chromatin diminution that is a naturally programmed phenomenon. We describe chromosome/DNA elimination in various organisms and present the current hypotheses on its origin, mechanisms, significance, and consequences.

KW - B chromosomes

KW - Chromosome drive

KW - Chromosome elimination

KW - Diminution

KW - Gene silencing

KW - Programmed DNA elimination

KW - Repetitive sequences

KW - Super-mendelian inheritance

KW - Chromatin

KW - Humans

KW - Male

KW - DNA/genetics

KW - Genetic Engineering

KW - Genome/genetics

KW - Female

KW - Chromosomes

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DO - 10.1016/j.ydbio.2022.03.008

M3 - Review article

C2 - 35321809

AN - SCOPUS:85126866541

SN - 0012-1606

VL - 486

SP - 15

EP - 25

JO - Developmental Biology

JF - Developmental Biology

ER -

Natural genetic engineering: A programmed chromosome/DNA elimination

Abstract

Keywords

ASJC Scopus subject areas

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