New insights into cellular functions of nuclear actin

Malgorzata Kloc; Priyanka Chanana; Nicole Vaughn; Ahmed Uosef; Jacek Z. Kubiak; Rafik M. Ghobrial

doi:10.3390/biology10040304

New insights into cellular functions of nuclear actin

Malgorzata Kloc, Priyanka Chanana, Nicole Vaughn, Ahmed Uosef, Jacek Z. Kubiak, Rafik M. Ghobrial

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Actin is one of the most abundant proteins in eukaryotic cells. There are different pools of nuclear actin often undetectable by conventional staining and commercial antibodies used to identify cytoplasmic actin. With the development of more sophisticated imaging and analytical techniques, it became clear that nuclear actin plays a crucial role in shaping the chromatin, genomic, and epigenetic landscape, transcriptional regulation, and DNA repair. This multifaceted role of nuclear actin is not only important for the function of the individual cell but also for the establishment of cell fate, and tissue and organ differentiation during development. Moreover, the changes in the nuclear, chromatin, and genomic architecture are preamble to various diseases. Here, we discuss some of the newly described functions of nuclear actin.

Original language	English (US)
Article number	304
Journal	Biology
Volume	10
Issue number	4
DOIs	https://doi.org/10.3390/biology10040304
State	Published - Apr 2021

Keywords

Chromatin remodeling
F actin
G actin
Intranuclear rods
Nuclear actin
Nuclear architecture
Rhoa

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Agricultural and Biological Sciences(all)

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title = "New insights into cellular functions of nuclear actin",

abstract = "Actin is one of the most abundant proteins in eukaryotic cells. There are different pools of nuclear actin often undetectable by conventional staining and commercial antibodies used to identify cytoplasmic actin. With the development of more sophisticated imaging and analytical techniques, it became clear that nuclear actin plays a crucial role in shaping the chromatin, genomic, and epigenetic landscape, transcriptional regulation, and DNA repair. This multifaceted role of nuclear actin is not only important for the function of the individual cell but also for the establishment of cell fate, and tissue and organ differentiation during development. Moreover, the changes in the nuclear, chromatin, and genomic architecture are preamble to various diseases. Here, we discuss some of the newly described functions of nuclear actin.",

keywords = "Chromatin remodeling, F actin, G actin, Intranuclear rods, Nuclear actin, Nuclear architecture, Rhoa",

author = "Malgorzata Kloc and Priyanka Chanana and Nicole Vaughn and Ahmed Uosef and Kubiak, {Jacek Z.} and Ghobrial, {Rafik M.}",

note = "Funding Information: Acknowledgments: We thank The William Stamps Farish Fund and Novartis for support to MK and RMG. During the writing of this article, JZK was supported by “Kos´ciuszko” grant # 508/2017/DA from the Polish Ministry of National Defense. Some of the images used to make figures were from the Servier Medical ART: SMART, smart.servier.com. Funding Information: We thank The William Stamps Farish Fund and Novartis for support to MK and RMG. During the writing of this article, JZK was supported by “Ko{\'s}ciuszko” grant # 508/2017/DA from the Polish Ministry of National Defense. Some of the images used to make figures were from the Servier Medical ART: SMART, smart.servier.com. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = apr,

doi = "10.3390/biology10040304",

language = "English (US)",

volume = "10",

journal = "Biology",

issn = "2079-7737",

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AU - Kloc, Malgorzata

AU - Chanana, Priyanka

AU - Vaughn, Nicole

AU - Uosef, Ahmed

AU - Kubiak, Jacek Z.

AU - Ghobrial, Rafik M.

N1 - Funding Information: Acknowledgments: We thank The William Stamps Farish Fund and Novartis for support to MK and RMG. During the writing of this article, JZK was supported by “Kos´ciuszko” grant # 508/2017/DA from the Polish Ministry of National Defense. Some of the images used to make figures were from the Servier Medical ART: SMART, smart.servier.com. Funding Information: We thank The William Stamps Farish Fund and Novartis for support to MK and RMG. During the writing of this article, JZK was supported by “Kościuszko” grant # 508/2017/DA from the Polish Ministry of National Defense. Some of the images used to make figures were from the Servier Medical ART: SMART, smart.servier.com. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/4

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N2 - Actin is one of the most abundant proteins in eukaryotic cells. There are different pools of nuclear actin often undetectable by conventional staining and commercial antibodies used to identify cytoplasmic actin. With the development of more sophisticated imaging and analytical techniques, it became clear that nuclear actin plays a crucial role in shaping the chromatin, genomic, and epigenetic landscape, transcriptional regulation, and DNA repair. This multifaceted role of nuclear actin is not only important for the function of the individual cell but also for the establishment of cell fate, and tissue and organ differentiation during development. Moreover, the changes in the nuclear, chromatin, and genomic architecture are preamble to various diseases. Here, we discuss some of the newly described functions of nuclear actin.

AB - Actin is one of the most abundant proteins in eukaryotic cells. There are different pools of nuclear actin often undetectable by conventional staining and commercial antibodies used to identify cytoplasmic actin. With the development of more sophisticated imaging and analytical techniques, it became clear that nuclear actin plays a crucial role in shaping the chromatin, genomic, and epigenetic landscape, transcriptional regulation, and DNA repair. This multifaceted role of nuclear actin is not only important for the function of the individual cell but also for the establishment of cell fate, and tissue and organ differentiation during development. Moreover, the changes in the nuclear, chromatin, and genomic architecture are preamble to various diseases. Here, we discuss some of the newly described functions of nuclear actin.

KW - Chromatin remodeling

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KW - G actin

KW - Intranuclear rods

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KW - Nuclear architecture

KW - Rhoa

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New insights into cellular functions of nuclear actin

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Keywords

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