RhoA-and actin-dependent functions of macrophages from the rodent cardiac transplantation model perspective-timing is the essence

Malgorzata Kloc; Ahmed Uosef; Martha Villagran; Robert Zdanowski; Jacek Z. Kubiak; Jarek Wosik; Rafik M. Ghobrial

doi:10.3390/biology10020070

RhoA-and actin-dependent functions of macrophages from the rodent cardiac transplantation model perspective-timing is the essence

Malgorzata Kloc, Ahmed Uosef, Martha Villagran, Robert Zdanowski, Jacek Z. Kubiak, Jarek Wosik, Rafik M. Ghobrial

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The small GTPase RhoA, and its down-stream effector ROCK kinase, and the interacting Rac1and and mTORC2 pathways, are the principal regulators of the actin cytoskeleton and actin-related functions in all eukaryotic cells, including the immune cells. As such, they also regulate the phenotypes and functions of macrophages in the immune response and beyond. Here, we review the results of our and other’s studies on the role of the actin and RhoA pathway in shaping the macrophage functions in general and macrophage immune response during the development of chronic (long term) rejection of allografts in the rodent cardiac transplantation model. We focus on the importance of timing of the macrophage functions in chronic rejection and how the circadian rhythm may affect the anti-chronic rejection therapies.

Original language	English (US)
Article number	70
Pages (from-to)	1-16
Number of pages	16
Journal	Biology
Volume	10
Issue number	2
DOIs	https://doi.org/10.3390/biology10020070
State	Published - Jan 20 2021

Keywords

Actin
Chronic rejection
Circadian rhythm
Macrophage
Mouse
ROCK
Rac1
Rat
RhoA
Timing
Transplantation

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Agricultural and Biological Sciences(all)

Access to Document

10.3390/biology10020070

Cite this

@article{d8ce0e6de28545cc9e69e8f5c4f2b017,

title = "RhoA-and actin-dependent functions of macrophages from the rodent cardiac transplantation model perspective-timing is the essence",

abstract = "The small GTPase RhoA, and its down-stream effector ROCK kinase, and the interacting Rac1and and mTORC2 pathways, are the principal regulators of the actin cytoskeleton and actin-related functions in all eukaryotic cells, including the immune cells. As such, they also regulate the phenotypes and functions of macrophages in the immune response and beyond. Here, we review the results of our and other{\textquoteright}s studies on the role of the actin and RhoA pathway in shaping the macrophage functions in general and macrophage immune response during the development of chronic (long term) rejection of allografts in the rodent cardiac transplantation model. We focus on the importance of timing of the macrophage functions in chronic rejection and how the circadian rhythm may affect the anti-chronic rejection therapies.",

keywords = "Actin, Chronic rejection, Circadian rhythm, Macrophage, Mouse, ROCK, Rac1, Rat, RhoA, Timing, Transplantation",

author = "Malgorzata Kloc and Ahmed Uosef and Martha Villagran and Robert Zdanowski and Kubiak, {Jacek Z.} and Jarek Wosik and Ghobrial, {Rafik M.}",

note = "Funding Information: Acknowledgments: We thank The William Stamps Farish Fund and Novartis for support to M.K. and R.M.G. During the writing of this article, J.Z.K. was supported by “Kos´ciuszko” grant # 5508/2017/DA from the Polish Ministry of National Defense. Some of the images used to make figures were from the Servier Medical ART: SMART, smart.servier.com. Funding Information: We thank The William Stamps Farish Fund and Novartis for support to M.K. and R.M.G. During the writing of this article, J.Z.K. was supported by ?Ko?ciuszko? grant # 5508/2017/DA from the Polish Ministry of National Defense. Some of the images used to make figures were from the Servier Medical ART: SMART, smart.servier.com. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = jan,

day = "20",

doi = "10.3390/biology10020070",

language = "English (US)",

volume = "10",

pages = "1--16",

journal = "Biology",

issn = "2079-7737",

publisher = "MDPI Multidisciplinary Digital Publishing Institute",

number = "2",

}

TY - JOUR

T1 - RhoA-and actin-dependent functions of macrophages from the rodent cardiac transplantation model perspective-timing is the essence

AU - Kloc, Malgorzata

AU - Uosef, Ahmed

AU - Villagran, Martha

AU - Zdanowski, Robert

AU - Kubiak, Jacek Z.

AU - Wosik, Jarek

AU - Ghobrial, Rafik M.

N1 - Funding Information: Acknowledgments: We thank The William Stamps Farish Fund and Novartis for support to M.K. and R.M.G. During the writing of this article, J.Z.K. was supported by “Kos´ciuszko” grant # 5508/2017/DA from the Polish Ministry of National Defense. Some of the images used to make figures were from the Servier Medical ART: SMART, smart.servier.com. Funding Information: We thank The William Stamps Farish Fund and Novartis for support to M.K. and R.M.G. During the writing of this article, J.Z.K. was supported by ?Ko?ciuszko? grant # 5508/2017/DA from the Polish Ministry of National Defense. Some of the images used to make figures were from the Servier Medical ART: SMART, smart.servier.com. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/1/20

Y1 - 2021/1/20

N2 - The small GTPase RhoA, and its down-stream effector ROCK kinase, and the interacting Rac1and and mTORC2 pathways, are the principal regulators of the actin cytoskeleton and actin-related functions in all eukaryotic cells, including the immune cells. As such, they also regulate the phenotypes and functions of macrophages in the immune response and beyond. Here, we review the results of our and other’s studies on the role of the actin and RhoA pathway in shaping the macrophage functions in general and macrophage immune response during the development of chronic (long term) rejection of allografts in the rodent cardiac transplantation model. We focus on the importance of timing of the macrophage functions in chronic rejection and how the circadian rhythm may affect the anti-chronic rejection therapies.

AB - The small GTPase RhoA, and its down-stream effector ROCK kinase, and the interacting Rac1and and mTORC2 pathways, are the principal regulators of the actin cytoskeleton and actin-related functions in all eukaryotic cells, including the immune cells. As such, they also regulate the phenotypes and functions of macrophages in the immune response and beyond. Here, we review the results of our and other’s studies on the role of the actin and RhoA pathway in shaping the macrophage functions in general and macrophage immune response during the development of chronic (long term) rejection of allografts in the rodent cardiac transplantation model. We focus on the importance of timing of the macrophage functions in chronic rejection and how the circadian rhythm may affect the anti-chronic rejection therapies.

KW - Actin

KW - Chronic rejection

KW - Circadian rhythm

KW - Macrophage

KW - Mouse

KW - ROCK

KW - Rac1

KW - Rat

KW - RhoA

KW - Timing

KW - Transplantation

UR - http://www.scopus.com/inward/record.url?scp=85099935765&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85099935765&partnerID=8YFLogxK

U2 - 10.3390/biology10020070

DO - 10.3390/biology10020070

M3 - Review article

C2 - 33498417

AN - SCOPUS:85099935765

SN - 2079-7737

VL - 10

SP - 1

EP - 16

JO - Biology

JF - Biology

IS - 2

M1 - 70

ER -

RhoA-and actin-dependent functions of macrophages from the rodent cardiac transplantation model perspective-timing is the essence

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this