Center for Cardiovascular Regeneration

Research output

Research output per year 1980 2011 2012 2013 2014 2015 2016 2024

• 72427 Citations
• 867 Article
• 129 Review article
• 37 Editorial
• 36 Conference contribution
• 103 More
  • 31 Chapter
  • 27 Letter
  • 22 Comment/debate
  • 6 Conference article
  • 6 Short survey
  • 4 Paper
  • 3 Foreword/postscript
  • 1 Chapter (peer-reviewed)
  • 1 Poster
  • 1 Other contribution
  • 1 Patent

Research output per year

Research output per year

Search results

• 2024

  Metal–Organic Framework as a New Type of Magnetothermally-Triggered On-Demand Release Carrier

  Ge, X., Mohapatra, J., Silva, E., He, G., Gong, L., Lyu, T., Madhogaria, R. P., Zhao, X., Cheng, Y., Al-Enizi, A. M., Nafady, A., Tian, J., Liu, J. P., Phan, M. H., Taraballi, F., Pettigrew, R. I. & Ma, S., Mar 22 2024, In: Small. 20, 12, 2306940.

  Research output: Contribution to journal › Article › peer-review

  • Metalorganic frameworks 100%
  • Iron oxides 82%
  • ferric oxide 79%
  • Nanoparticles 62%
  • Drug Liberation 62%
  1 Scopus citations
• 2023

  A_2AR-mediated lymphangiogenesis via VEGFR2 signaling prevents salt-sensitive hypertension

  Zhuang, T., Lei, Y., Chang, J. J., Zhou, Y. P., Li, Y., Li, Y. X., Yang, Y. F., Chen, M. H., Meng, T., Fu, S. M., Huang, L. H., Cheang, W. S., Cooke, J. P., Dong, Z. H., Bai, Y. N. & Ruan, C. C., Aug 1 2023, In: European heart journal. 44, 29, p. 2730-2742 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Lymphangiogenesis 100%
  • Salts 64%
  • Endothelial Cells 54%
  • Hypertension 47%
  • Lymphatic Vessels 38%
  4 Scopus citations

• An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis

  Abe, J-I., Imanishi, M., Li, S., Zhang, A., Ko, K. A., Samanthapudi, V. S. K., Lee, L-L., Bojorges, A. P., Gi, Y. J., Hobbs, B. P., Deswal, A., Herrmann, J., Lin, S. H., Chini, E. N., Shen, Y. H., Schadler, K. L., Nguyen, T-H-M., Gupte, A. A., Reyes-Gibby, C., Yeung, S-C. J., & 14 othersAbe, R. J., Olmsted-Davis, E. A., Krishnan, S., Dantzer, R., Palaskas, N. L., Cooke, J. P., Pownall, H. J., Yoshimoto, M., Fujiwara, K., Hamilton, D. J., Burks, J. K., Wang, G., Le, N-T. & Kotla, S., Jun 23 2023, In: Circulation Research. 133, 1, p. 25-44 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitogen-Activated Protein Kinase 7 100%
  • Atherosclerosis 47%
  • Phosphotransferases 15%
  • Clustered Regularly Interspaced Short Palindromic Repeats 13%
  • Cellular Senescence 13%
  4 Scopus citations

• A relay velocity model infers cell-dependent RNA velocity

  Li, S., Zhang, P., Chen, W., Ye, L., Brannan, K. W., Le, N. T., Abe, J. I., Cooke, J. P. & Wang, G., Apr 3 2023, In: Nature Biotechnology. 42, 1, p. 99-108 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA 100%
  • Velocity 69%
  • RNA Sequencing 45%
  • Kinetics 26%
  • RNA Sequence Analysis 20%
  10 Scopus citations

• Continuous cuffless blood pressure monitoring with a wearable ring bioimpedance device

  Sel, K., Osman, D., Huerta, N., Edgar, A., Pettigrew, R. I. & Jafari, R., Mar 30 2023, In: npj Digital Medicine. 6, 1, p. 59 59.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Blood pressure 100%
  • Blood Pressure 55%
  • Equipment and Supplies 51%
  • Monitoring 48%
  • Skin 28%
  14 Scopus citations

• Coronary microvascular health in symptomatic patients with prior COVID-19 infection: an updated analysis

  Ahmed, A. I., Al Rifai, M., Alahdab, F., Saad, J. M., Han, Y., Alfawara, M. S., Nayfeh, M., Malahfji, M., Nabi, F., Mahmarian, J. J., Cooke, J. P., Zoghbi, W. A. & Al-Mallah, M. H., Nov 1 2023, In: European Heart Journal Cardiovascular Imaging. 24, 11, p. 1544-1554 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Coronavirus 100%
  • Severe Acute Respiratory Syndrome 51%
  • Health 38%
  • Infections 37%
  • Positron-Emission Tomography 18%

• Design and rationale of re-energize fontan: Randomized exercise intervention designed to maximize fitness in fontan patients

  Selamet Tierney, E. S., Palaniappan, L., Leonard, M., Long, J., Myers, J., Dávila, T., Lui, M. C., Kogan, F., Olson, I., Punn, R., Desai, M., Schneider, L. M., Wang, C. H., Cooke, J. P. & Bernstein, D., May 2023, In: American Heart Journal. 259, p. 68-78 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Exercise 100%
  • Pediatrics 35%
  • Muscles 26%
  • Muscle Strength 22%
  • Morbidity 19%
  3 Scopus citations

• Disrupted stiffness ratio alters nuclear mechanosensing

  Walther, B. K., Sears, A. P., Mojiri, A., Avazmohammadi, R., Gu, J., Chumakova, O. V., Rajeeva Pandian, N. K., Dominic, A., Martiel, J. L., Yazdani, S. K., Cooke, J. P., Ohayon, J. & Pettigrew, R. I., Oct 4 2023, In: Matter. 6, 10, p. 3608-3630 23 p.

  Research output: Contribution to journal › Article › peer-review

  • Shear Stress 100%
  • Endothelial cells 82%
  • Shear 76%
  • Stiffness 58%
  • Shear stress 51%
  1 Scopus citations

• Electrically stimulated gene expression under exogenously applied electric fields

  Abasi, S., Jain, A., Cooke, J. P. & Guiseppi-Elie, A., 2023, In: Frontiers in Molecular Biosciences. 10, p. 1161191 1161191.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Electric Impedance 100%
  • Tissue Engineering 96%
  • Electric Stimulation 90%
  • Electric Field 88%
  • Electrical Resistance 76%
  1 Scopus citations

• Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition

  Nguyen, M. T. H., Imanishi, M., Li, S., Chau, K., Banerjee, P., Velatooru, L. R., Ko, K. A., Samanthapudi, V. S. K., Gi, Y. J., Lee, L. L., Abe, R. J., McBeath, E., Deswal, A., Lin, S. H., Palaskas, N. L., Dantzer, R., Fujiwara, K., Borchardt, M. K., Turcios, E. B., Olmsted-Davis, E. A., & 5 othersKotla, S., Cooke, J. P., Wang, G., Abe, J. I. & Le, N. T., 2023, In: Frontiers in Cardiovascular Medicine. 10, p. 1187490 1187490.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • isopeptidase 100%
  • SUMO-1 Protein 96%
  • Checkpoint Kinase 1 87%
  • Endothelial Cells 19%
  • Phosphorylation 13%

• Epigenetic landscape reveals MECOM as an endothelial lineage regulator

  Lv, J., Meng, S., Gu, Q., Zheng, R., Gao, X., Kim, J. D., Chen, M., Xia, B., Zuo, Y., Zhu, S., Zhao, D., Li, Y., Wang, G., Wang, X., Meng, Q., Cao, Q., Cooke, J. P., Fang, L., Chen, K. & Zhang, L., Apr 25 2023, In: Nature Communications. 14, 1, p. 2390 2390.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • regulators 100%
  • Epigenomics 68%
  • Endothelial Cells 58%
  • Cell Lineage 47%
  • Enhancer 46%
  7 Scopus citations

• Long noncoding RNA LEENE promotes angiogenesis and ischemic recovery in diabetes models

  Tang, X., Luo, Y., Yuan, D., Calandrelli, R., Malhi, N. K., Sriram, K., Miao, Y., Lou, C. H., Tsark, W., Tapia, A., Chen, A. T., Zhang, G., Roeth, D., Kalkum, M., Wang, Z. V., Chien, S., Natarajan, R., Cooke, J. P., Zhong, S. & Chen, Z. B., Feb 1 2023, In: Journal of Clinical Investigation. 133, 3, e161759.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Long Noncoding RNA 100%
  • Endothelial Cells 51%
  • Perfusion 34%
  • Ischemia 34%
  • Extremities 34%
  9 Scopus citations

• Long noncoding RNAs are substrates for cytoplasmic capping enzyme

  Mukherjee, A., Islam, S., Kieser, R. E., Kiss, D. L. & Mukherjee, C., Apr 2023, In: FEBS Letters. 597, 7, p. 947-961 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Long Noncoding RNA 100%
  • Enzymes 50%
  • Complementary DNA 38%
  • Subcellular Localization 25%
  • Messenger RNA 21%

• Metabolic dysregulation impairs lymphocyte function during severe SARS-CoV-2 infection

  Gurshaney, S., Morales-Alvarez, A., Ezhakunnel, K., Manalo, A., Huynh, T. H., Abe, J. I., Le, N. T., Weiskopf, D., Sette, A., Lupu, D. S., Gardell, S. J. & Nguyen, H., Apr 7 2023, In: Communications Biology. 6, 1, 374.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • lymphocytes 56%
  • Metabolic 55%
  • Pharmacological Metabolism 52%
  • Lymphocytes 46%
  2 Scopus citations

• Physics-informed neural networks for modeling physiological time series for cuffless blood pressure estimation

  Sel, K., Mohammadi, A., Pettigrew, R. I. & Jafari, R., Jun 9 2023, In: npj Digital Medicine. 6, 1, p. 110 110.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Physics 100%
  • Blood pressure 94%
  • Time series 70%
  • erbulozole 64%
  • Blood Pressure 52%
  2 Scopus citations

• Telomerase mRNA Enhances Human Skin Engraftment for Wound Healing

  Chang, D. F., Court, K. A., Holgate, R., Davis, E. A., Bush, K. A., Quick, A. P., Spiegel, A. J., Rahimi, M., Cooke, J. P. & Godin, B., Aug 24 2023, (E-pub ahead of print) In: Advanced Healthcare Materials. 13, 2, p. e2302029 2302029.

  Research output: Contribution to journal › Article › peer-review

  • Messenger RNA 100%
  • Telomerase 81%
  • Wound Healing 62%
  • Skin 61%
  • Lipid 36%
  1 Scopus citations

• TNIK regulation of interferon signaling and endothelial cell response to virus infection

  Chau, K. M., Dominic, A., Davis, E. L., Kotla, S., Berrios, E. T., Fahim, A., Arunesh, A., Li, S., Zhao, D., Chen, K., Davis, A. R., Nguyen, M. T. H., Wang, Y., Evans, S. E., Wang, G., Cooke, J. P., Abe, J. I., Huston, D. P. & Le, N. T., 2023, In: Frontiers in cardiovascular medicine. 10, p. 1213428 1213428.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interferons 100%
  • Phosphotransferases 84%
  • Endothelial Cells 80%
  • Virus Diseases 80%
  • RNA-Seq 31%
• 2022

  AIBP Regulates Metabolism of Ketone and Lipids but Not Mitochondrial Respiration

  Kim, J. D., Zhou, T., Zhang, A., Li, S., Gupte, A. A., Hamilton, D. J. & Fang, L., Nov 17 2022, In: Cells. 11, 22, 3643.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ketones 100%
  • NAD 81%
  • Lipid Metabolism 75%
  • Respiration 65%
  • alpha-Linolenic Acid 42%

• At the nexus of science, engineering, and medicine: Pasteur's quadrant reconsidered

  Pettigrew, R. I. & Cooke, J. P., Jul 2022, In: PNAS nexus. 1, 3, p. pgac092

  Research output: Contribution to journal › Article › peer-review

  • Nexus 100%
  • Medicine 51%
  • Vertical Dimension 12%
  • Hydrodynamics 10%
  • Financial Management 10%

• At the nexus of science, engineering, and medicine: Pasteur's quadrant reconsidered

  Pettigrew, R. I. & Cooke, J. P., Jul 1 2022, In: PNAS Nexus. 1, 3, pgac092.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • medicine 100%
  • applied research 72%
  • science 65%
  • engineering 63%
  • innovation 34%
  1 Scopus citations

• CHD6 promotes broad nucleosome eviction for transcriptional activation in prostate cancer cells

  Zhao, D., Zhang, M., Huang, S., Liu, Q., Zhu, S., Li, Y., Jiang, W., Kiss, D. L., Cao, Q., Zhang, L. & Chen, K., Nov 28 2022, In: Nucleic Acids Research. 50, 21, p. 12186-12201 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nucleosomes 100%
  • Transcriptional Activation 77%
  • Prostatic Neoplasms 67%
  • Chromatin 56%
  • Chromatin Immunoprecipitation Sequencing 27%
  3 Scopus citations

• Dynamic Tumor-Specific MHC-II Immuno-PET Predicts the Efficacy of Checkpoint Inhibitor Immunotherapy in Melanoma

  Yang, Z., Li, F., Huang, Y., Yin, N., Chu, J., Ma, Y., Pettigrew, R. I., Hamilton, D. J., Martin, D. R. & Li, Z., Nov 1 2022, In: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 63, 11, p. 1708-1714 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Major Histocompatibility Complex 100%
  • Immunotherapy 86%
  • Melanoma 81%
  • Neoplasms 31%
  • Interferons 21%
  4 Scopus citations

• Endothelial thioredoxin interacting protein (TXNIP) modulates endothelium-dependent vasorelaxation in hyperglycemia

  Lam, Y. T., Tan, R. P., Michael, P., Yang, N., Dunn, L. L., Cooke, J. P., Celermajer, D. S., Wise, S. G. & Ng, M. K. C., Sep 2022, In: Microvascular Research. 143, p. 104396 104396.

  Research output: Contribution to journal › Article › peer-review

  • Thioredoxin 100%
  • Thioredoxins 99%
  • Vasodilation 76%
  • Hyperglycemia 71%
  • Endothelium 69%
  3 Scopus citations

• MAGI1 inhibits interferon signaling to promote influenza A infection

  Wang, Y., Abe, J. I., Chau, K. M., Wang, Y., Vu, H. T., Reddy Velatooru, L., Gulraiz, F., Imanishi, M., Samanthapudi, V. S. K., Nguyen, M. T. H., Ko, K. A., Lee, L. L., Thomas, T. N., Olmsted-Davis, E. A., Kotla, S., Fujiwara, K., Cooke, J. P., Zhao, D., Evans, S. E. & Le, N. T., Aug 23 2022, In: Frontiers in Cardiovascular Medicine. 9, 36082118, p. 791143 791143.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Influenza A virus 100%
  • Human Influenza 83%
  • Interferons 83%
  • Interferon Regulatory Factor-3 73%
  • Infections 43%
  1 Scopus citations

• Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?

  Le, N. T., Olmsted-Davis, E. A. & Abe, J. I., Mar 2022, In: Clinical Science. 136, 5, p. 379-382 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Osteoprotegerin 100%
  • Oxidative Stress 57%
  • Inflammation 46%
  • Blood Vessels 46%
  • Reactive Oxygen Species 20%

• Polygenic risk impacts PDGFRA mutation penetrance in non-syndromic cleft lip and palate

  Yu, Y., Alvarado, R., Petty, L. E., Bohlender, R. J., Shaw, D. M., Below, J. E., Bejar, N., Ruiz, O. E., Tandon, B., Eisenhoffer, G. T., Kiss, D. L., Huff, C. D., Letra, A. & Hecht, J. T., Jul 15 2022, In: Human Molecular Genetics. 31, 14, p. 2348-2357 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Penetrance 100%
  • Cleft Lip 99%
  • Cleft Palate 95%
  • Mutation 48%
  • Multifactorial Inheritance 15%
  5 Scopus citations

• Radiation therapy induces immunosenescence mediated by p90RSK

  Imanishi, M., Cheng, H., Kotla, S., Deswal, A., Le, N. T., Chini, E., Ko, K. A., Samanthapudi, V. S. K., Lee, L. L., Herrmann, J., Xu, X., Reyes-Gibby, C., Yeung, S. C. J., Schadler, K. L., Yusuf, S. W., Liao, Z., Nurieva, R., Amir, E. A. D., Burks, J. K., Palaskas, N. L., & 5 othersCooke, J. P., Lin, S. H., Kobayashi, M., Yoshimoto, M. & Abe, J. I., Nov 7 2022, In: Frontiers in cardiovascular medicine. 9, 988713.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Immunosenescence 100%
  • Radiotherapy 47%
  • Cardiovascular Diseases 35%
  • B-Lymphocytes 30%
  • Cellular Senescence 21%
  3 Scopus citations

• RBFOX2 is required for establishing RNA regulatory networks essential for heart development

  Verma, S. K., Deshmukh, V., Thatcher, K., Belanger, K. A. K., Rhyner, A. M., Meng, S., Holcomb, R. J., Bressan, M., Martin, J. F., Cooke, J. P., Wythe, J. D., Widen, S. G., Lincoln, J. & Kuyumcu-Martinez, M. N., Feb 28 2022, In: Nucleic Acids Research. 50, 4, p. 2270-2286 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hypoplastic Left Heart Syndrome 100%
  • RNA 59%
  • Heart 56%
  • Extracellular Matrix 48%
  • Alternative Splicing 46%
  18 Scopus citations

• Vascular senescence in progeria: role of endothelial dysfunction

  Xu, Q., Mojiri, A., Boulahouache, L., Morales, E., Walther, B. K. & Cooke, J. P., Jul 2022, In: European heart journal open. 2, 4, p. oeac047

  Research output: Contribution to journal › Article › peer-review

  • Progeria 100%
  • Blood Vessels 38%
  • Endothelial Cells 22%
  • Galactosidases 13%
  • Lamin Type A 12%

• Vascular senescence in progeria: role of endothelial dysfunction

  Xu, Q., Mojiri, A., Boulahouache, L., Morales, E., Walther, B. K. & Cooke, J. P., Jul 1 2022, In: European Heart Journal Open. 2, 4

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Progeria 100%
  • Blood Vessels 38%
  • Endothelial Cells 22%
  • Galactosidases 13%
  • Lamin Type A 12%
  10 Scopus citations
• 2021

  3D Bioprinted Multicellular Vascular Models

  Gold, K. A., Saha, B., Rajeeva Pandian, N. K., Walther, B. K., Palma, J. A., Jo, J., Cooke, J. P., Jain, A. & Gaharwar, A. K., Nov 3 2021, In: Advanced Healthcare Materials. 10, 21, p. e2101141 2101141.

  Research output: Contribution to journal › Article › peer-review

  • Blood vessels 100%
  • Toxin 81%
  • Shear 77%
  • Cytokines 71%
  • Bioprinting 64%
  33 Scopus citations

• Corrigendum: p90RSK-MAGI1 Module Controls Endothelial Permeability by Post-translational Modifications of MAGI1 and Hippo Pathway

  Abe, R. J., Savage, H., Imanishi, M., Banerjee, P., Kotla, S., Paez-Mayorga, J., Taunton, J., Fujiwara, K., Won, J. H., Yusuf, S. W., Palaskas, N. L., Banchs, J., Lin, S. H., Schadler, K. L., Abe, J-I. & Le, N-T., 2021, In: Frontiers in cardiovascular medicine. 8, p. 663486

  Research output: Contribution to journal › Article › peer-review

  • Post Translational Protein Processing 100%
  • Permeability 83%

• Disturbed flow-induced FAK K152 SUMOylation initiates the formation of pro-inflammation positive feedback loop by inducing reactive oxygen species production in endothelial cells

  Velatooru, L. R., Abe, R. J., Imanishi, M., Gi, Y. J., Ko, K. A., Heo, K. S., Fujiwara, K., Le, N. T. & Kotla, S., Dec 2021, In: Free Radical Biology and Medicine. 177, p. 404-418 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Sumoylation 100%
  • Focal Adhesion Protein-Tyrosine Kinases 92%
  • Reactive Oxygen Metabolite 69%
  • Reactive Oxygen Species 59%
  • Endothelial Cells 55%
  9 Scopus citations

• Endothelial Dysfunction-related Neurological Bleeds with Continuous Flow-Left Ventricular Assist Devices Measured by Digital Thermal Monitor

  Ali, A., Uribe, C., Araujo-Gutierrez, R., Cruz-Solbes, A. S., Marcos-Abdala, H. G., Youker, K. A., Guha, A., Torre-Amione, G., Nguyen, D. T., Graviss, E. A., Cooke, J. P. & Bhimaraj, A., May 1 2021, In: ASAIO Journal. 67, 5, p. 561-566 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Left ventricular assist devices 100%
  • Heart-Assist Devices 74%
  • Valve 67%
  • Hot Temperature 48%
  • Blood Vessels 37%
  2 Scopus citations

• Fli1+ cells transcriptional analysis reveals an Lmo2-Prdm16 axis in angiogenesis

  Matrone, G., Xia, B., Chen, K., Denvir, M. A., Baker, A. H. & Cooke, J. P., Aug 3 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, e2008559118.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Endothelial Cells 100%
  • Zebrafish 58%
  • Proto-Oncogene Protein c-fli-1 38%
  • Morpholinos 25%
  • Zinc Fingers 21%
  7 Scopus citations

• Impact of malapposed and overlapping stents on hemodynamics: A 2d parametric computational fluid dynamics study

  Lagache, M., Coppel, R., Finet, G., Derimay, F., Pettigrew, R. I., Ohayon, J. & Malvè, M., Apr 2 2021, In: Mathematics. 9, 8, 795.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stent 100%
  • Hemodynamics 86%
  • Stents 78%
  • Computational Fluid Dynamics 77%
  • Overlapping 63%
  8 Scopus citations

• Induced endothelial cells from peripheral arterial disease patients and neonatal fibroblasts have comparable angiogenic properties

  Hywood, J. D., Sadeghipour, S., Clayton, Z. E., Yuan, J., Stubbs, C., Wong, J. W. T., Cooke, J. P. & Patel, S., Aug 2021, In: PLoS ONE. 16, 8, p. e0255075 e0255075.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Angiogenic 100%
  • Peripheral Arterial Disease 75%
  • endothelial cells 69%
  • fibroblasts 60%
  • Fibroblasts 50%
  1 Scopus citations

• MACMIC Reveals A Dual Role of CTCF in Epigenetic Regulation of Cell Identity Genes

  Wang, G., Xia, B., Zhou, M., Lv, J., Zhao, D., Li, Y., Bu, Y., Wang, X., Cooke, J. P., Cao, Q., Lee, M. G., Zhang, L. & Chen, K., Feb 2021, In: Genomics, Proteomics and Bioinformatics. 19, 1, p. 140-153 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Gene 100%
  • Epigenomics 89%
  • Cell 75%
  • Correlation Analysis 71%
  • Genes 41%
  4 Scopus citations

• Mechanotransduction-on-chip: Vessel-chip model of endothelial YAP mechanobiology reveals matrix stiffness impedes shear response

  Walther, B. K., Rajeeva Pandian, N. K., Gold, K. A., Kiliç, E. S., Sama, V., Gu, J., Gaharwar, A. K., Guiseppi-Elie, A., Cooke, J. P. & Jain, A., May 7 2021, In: Lab on a Chip. 21, 9, p. 1738-1751 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Biophysics 100%
  • Stiffness matrix 78%
  • Proteins 66%
  • Shear 66%
  • Protein 30%
  17 Scopus citations

• Metabolic flexibility maintains proliferation and migration of FGFR signaling-deficient lymphatic endothelial cells

  Song, H., Zhu, J., Han, F., Fang, L. & Yu, P., Aug 30 2021, In: J Biol Chem. 294, 4

  Research output: Contribution to journal › Article › peer-review

  • Fibroblast Growth Factor Receptors 100%
  • Endothelial Cells 57%
  • Carnitine O-Palmitoyltransferase 54%
  • Glycolysis 40%
  • Fatty Acids 33%

• Metabolic flexibility maintains proliferation and migration of FGFR signaling–deficient lymphatic endothelial cells

  Song, H., Zhu, J., Li, P., Han, F., Fang, L. & Yu, P., Oct 1 2021, In: Journal of Biological Chemistry. 279, 4, 101149.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fibroblast Growth Factor Receptors 100%
  • Metabolic 62%
  • Flexibility 61%
  • Endothelial Cells 57%
  • Carnitine O-Palmitoyltransferase 54%
  3 Scopus citations

• New Directions in Therapeutic Angiogenesis and Arteriogenesis in Peripheral Arterial Disease

  Annex, B. H. & Cooke, J. P., Jun 11 2021, In: Circulation Research. 128, 12, p. 1944-1957 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Peripheral Arterial Disease 100%
  • Direction compound 65%
  • Extremities 37%
  • Cell- and Tissue-Based Therapy 19%
  • Arteries 14%
  73 Scopus citations

• Nuclear S-nitrosylation impacts tissue regeneration in zebrafish

  Matrone, G., Jung, S. Y., Choi, J. M., Jain, A., Leung, H. C. E., Rajapakshe, K., Coarfa, C., Rodor, J., Denvir, M. A., Baker, A. H. & Cooke, J. P., Dec 1 2021, In: Nature Communications. 12, 1, 6282.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • regeneration 100%
  • Zebrafish 91%
  • Nitric Oxide 84%
  • Regeneration 75%
  • nitric oxide 54%
  9 Scopus citations

• Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation

  Kotla, S., Zhang, A., Imanishi, M., Ko, K. A., Lin, S. H., Gi, Y. J., Moczygemba, M., Isgandarova, S., Schadler, K. L., Chung, C., Milgrom, S. A., Banchs, J., Yusuf, S. W., Amaya, D. N., Guo, H., Thomas, T. N., Shen, Y. H., Deswal, A., Herrmann, J., Kleinerman, E. S., & 15 othersEntman, M. L., Cooke, J. P., Schifitto, G., Maggirwar, S. B., McBeath, E., Gupte, A. A., Krishnan, S., Patel, Z. S., Yoon, Y., Burks, J. K., Fujiwara, K., Brookes, P. S., Le, N-T., Hamilton, D. J. & Abe, J-I., Nov 2021, In: Redox Biology. 47, p. 102132 102132.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Poly(ADPribose) 100%
  • Poly(ADP-ribose) Polymerases 87%
  • Cellular Senescence 80%
  • Ionizing Radiation 71%
  • Coronary Artery Disease 60%
  17 Scopus citations

• Precision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease

  Atigh, M. K., Goel, E., Erwin, M., Greer, R., Ohayon, J., Pettigrew, R. I. & Yazdani, S. K., Dec 2021, In: Scientific Reports. 11, 1, 18676.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Peripheral Arterial Disease 100%
  • Pressure 58%
  • Swine 47%
  • Pharmaceutical Preparations 37%
  • Carotid Arteries 29%
  3 Scopus citations

• Rethinking Teaching Team-Based Learning: The Challenges and Strategies for Medical Education in a Pandemic

  Li, Y., Sears, N. A., Murray, I. V. J. & Yadav, K. K., Dec 2021, In: AERA Open. 7

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • team teaching 100%
  • Medical Education 86%
  • Pandemics 84%
  • Distance Education 74%
  • Teaching 69%
  2 Scopus citations

• Role of Endothelial and Mesenchymal Cell Transitions in Heart Failure and Recovery Thereafter

  Wang, G., Cruz, A. S., Youker, K., Marcos-Abdala, H. G., Thandavarayan, R. A., Cooke, J. P., Torre-Amione, G., Chen, K. & Bhimaraj, A., Jan 15 2021, In: Frontiers in Genetics. 11, p. 609262 609262.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Heart-Assist Devices 100%
  • Endothelial Cells 83%
  • Heart Failure 82%
  • Genes 45%
  • cadherin 5 38%
  5 Scopus citations

• Systemic metabolite profiling reveals sexual dimorphism of AIBP control of metabolism in mice

  Kim, J. D., Zhu, L., Sun, Q. & Fang, L., Apr 2021, In: PLoS ONE. 16, 4 April, e0248964.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • sexual dimorphism 100%
  • Sex Characteristics 91%
  • binding proteins 84%
  • Carrier Proteins 83%
  • Pharmacological Metabolism 75%
  8 Scopus citations

• Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice

  Mojiri, A., Walther, B. K., Jiang, C., Matrone, G., Holgate, R., Xu, Q., Morales, E., Wang, G., Gu, J., Wang, R. & Cooke, J. P., Nov 7 2021, In: European heart journal. 42, 42, p. 4352-4369 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Progeria 100%
  • Telomerase 75%
  • Longevity 59%
  • Blood Vessels 38%
  • Endothelial Cells 29%
  36 Scopus citations

• Unsupervised learning for automated detection of coronary artery disease subgroups

  Flores, A. M., Schuler, A., Eberhard, A. V., Olin, J. W., Cooke, J. P., Leeper, N. J., Shah, N. H. & Ross, E. G., Dec 7 2021, In: Journal of the American Heart Association. 10, 23, e021976.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Unsupervised Machine Learning 100%
  • Coronary Artery Disease 69%
  • Learning 61%
  • Cluster Analysis 49%
  • Risk Assessment 46%
  18 Scopus citations